{"doi":"10.1016/j.celrep.2020.108498","title":"Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells","abstract":"Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell development, the roles of this transcription factor and its upstream cytokines interleukin-2 (IL-2) and IL-15 during infection have not been carefully investigated. In this study, we investigate how STAT5 regulates transcription during viral infection. We demonstrate that STAT5 is induced in NK cells by IL-12 and STAT4 early after infection and that partial STAT5 deficiency results in a defective capacity of NK cells to generate long-lived memory cells. Furthermore, we find a functional dichotomy of IL-2 and IL-15 signaling outputs during viral infection, whereby both cytokines drive clonal expansion, but only IL-15 is required for memory NK cell survival. We thus highlight a role for STAT5 signaling in promoting an optimal anti-viral NK cell response.","journal":"Cell Reports","year":2020,"id":61090,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":322859,"name":"Simon Grassmann","orcid":"0000-0002-8336-3418","position":1,"is_corresponding":false},{"id":322860,"name":"Colleen M. Lau","orcid":"0000-0001-7538-094X","position":2,"is_corresponding":false},{"id":322861,"name":"Moritz Rapp","orcid":"0000-0001-5104-7683","position":3,"is_corresponding":false},{"id":291945,"name":"Alejandro V. Villarino","orcid":"0000-0001-8068-2176","position":4,"is_corresponding":false},{"id":322862,"name":"Christin Friedrich","orcid":"0000-0003-1866-254X","position":5,"is_corresponding":false},{"id":80234,"name":"Georg Gasteiger","orcid":"0000-0001-6986-127X","position":6,"is_corresponding":false},{"id":291946,"name":"John J. O’Shea","orcid":"0000-0002-6456-9752","position":7,"is_corresponding":false},{"id":61584,"name":"Joseph C. Sun","orcid":"0000-0001-8062-9033","position":8,"is_corresponding":false},{"id":322858,"name":"Gabriela M. Wiedemann","orcid":"0000-0001-6138-9791","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-18T21:09:27.985420Z","pmid":"33326784","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}