{"doi":"10.1016/j.celrep.2020.108486","title":"Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex","abstract":"without EMRE. We further show that EMRE may facilitate MCU opening by stabilizing the open state in a conserved MCU gating mechanism, present also in non-metazoan MCU homologs. These results provide insights into the evolution of the uniporter machinery and elucidate the mechanism underlying the physiologically crucial EMRE-dependent MCU activation process.","journal":"Cell Reports","year":2020,"id":96230,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9544,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477268,"name":"Chen-Wei Tsai","orcid":"0009-0000-2469-8966","position":1,"is_corresponding":false},{"id":477269,"name":"Enrique Balderas","orcid":"0000-0001-8780-9272","position":2,"is_corresponding":false},{"id":477270,"name":"Madison Rodriguez","orcid":"0000-0001-7000-5462","position":3,"is_corresponding":false},{"id":477271,"name":"Dipayan Chaudhuri","orcid":"0000-0003-0605-7334","position":4,"is_corresponding":false},{"id":477272,"name":"Ming-Feng Tsai","orcid":"0000-0003-4277-1885","position":5,"is_corresponding":false},{"id":477267,"name":"Anna M. Van Keuren","orcid":"0000-0001-7034-101X","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"33296646","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}