{"doi":"10.1016/j.celrep.2020.108473","title":"Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis","abstract":"A role for cancer cell epithelial-to-mesenchymal transition (EMT) in cancer is well established. Here, we show that, in addition to cancer cell EMT, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition (MET) in host mesenchymal stem cells (MSCs). These reprogrammed MSCs, termed carcinoma-associated MSCs (CA-MSCs), acquire pro-tumorigenic functions and directly bind cancer cells to serve as a metastatic driver/chaperone. Cancer cells induce this epigenomic MET characterized by enhancer-enriched DNA hypermethylation, altered chromatin accessibility, and differential histone modifications. This phenomenon appears clinically relevant, as CA-MSC MET is highly correlated with patient survival. Mechanistically, mirroring MET observed in development, MET in CA-MSCs is mediated by WT1 and EZH2. Importantly, EZH2 inhibitors, which are clinically available, significantly inhibited CA-MSC-mediated metastasis in mouse models of ovarian cancer.","journal":"Cell Reports","year":2020,"id":55269,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":285618,"name":"Huda I. Atiya","orcid":"0000-0001-9850-102X","position":1,"is_corresponding":false},{"id":285619,"name":"Yeh Wang","orcid":"0000-0003-3185-4802","position":2,"is_corresponding":false},{"id":285620,"name":"Thomas R. Pisanic","orcid":"0000-0001-5796-0836","position":3,"is_corresponding":false},{"id":246688,"name":"Tza‐Huei Wang","orcid":"0000-0002-3540-9354","position":4,"is_corresponding":false},{"id":39770,"name":"Ie‐Ming Shih","orcid":null,"position":5,"is_corresponding":false},{"id":285621,"name":"Kelly K. Foy","orcid":"0000-0002-7695-4922","position":6,"is_corresponding":false},{"id":285622,"name":"Leonard Frisbie","orcid":"0000-0001-8996-4292","position":7,"is_corresponding":false},{"id":247749,"name":"Ronald J. Buckanovich","orcid":"0000-0002-5665-9790","position":8,"is_corresponding":false},{"id":285623,"name":"Alison A. Chomiak","orcid":"0000-0002-5036-3390","position":9,"is_corresponding":false},{"id":285624,"name":"Rochelle L. Tiedemann","orcid":"0009-0008-8408-9984","position":10,"is_corresponding":false},{"id":282215,"name":"Scott B. Rothbart","orcid":"0000-0003-1631-5392","position":11,"is_corresponding":false},{"id":285625,"name":"Chelsea Chandler","orcid":"0000-0002-9409-0937","position":12,"is_corresponding":false},{"id":14040,"name":"Hui Shen","orcid":"0000-0001-9767-4084","position":13,"is_corresponding":false},{"id":247748,"name":"Lan Coffman","orcid":"0000-0002-3753-1652","position":14,"is_corresponding":false},{"id":69738,"name":"Huihui Fan","orcid":"0000-0003-4233-5389","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-18T21:04:59.506324Z","pmid":"33296650","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}