{"doi":"10.1016/j.celrep.2020.108429","title":"Multi-omic, Single-Cell, and Biochemical Profiles of Astronauts Guide Pharmacological Strategies for Returning to Gravity","abstract":"The National Aeronautics and Space Administration (NASA) Twins Study created an integrative molecular profile of an astronaut during NASA's first 1-year mission on the International Space Station (ISS) and included comparisons to an identical Earth-bound twin. The unique biochemical profiles observed when landing on Earth after such a long mission (e.g., spikes in interleukin-1 [IL-1]/6/10, c-reactive protein [CRP], C-C motif chemokine ligand 2 [CCL2], IL-1 receptor antagonist [IL-1ra], and tumor necrosis factor alpha [TNF-α]) opened new questions about the human body's response to gravity and how to plan for future astronauts, particularly around initiation or resolution of inflammation. Here, single-cell, multi-omic (100-plex epitope profile and gene expression) profiling of peripheral blood mononuclear cells (PBMCs) showed changes to blood cell composition and gene expression post-flight, specifically for monocytes and dendritic cell precursors. These were consistent with flight-induced cytokine and immune system stress, followed by skeletal muscle regeneration in response to gravity. Finally, we examined these profiles relative to 6-month missions in 28 other astronauts and detail potential pharmacological interventions for returning to gravity in future missions.","journal":"Cell Reports","year":2020,"id":56629,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7736,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237408,"name":"Christopher R. Chin","orcid":"0000-0002-2140-3197","position":1,"is_corresponding":false},{"id":296613,"name":"Delia Tomoiaga","orcid":null,"position":2,"is_corresponding":false},{"id":227764,"name":"Matthew MacKay","orcid":"0000-0002-1848-0829","position":3,"is_corresponding":false},{"id":111964,"name":"Christina Chang","orcid":null,"position":4,"is_corresponding":false},{"id":231221,"name":"Daniel Butler","orcid":"0000-0002-3687-8419","position":5,"is_corresponding":false},{"id":227763,"name":"Ebrahim Afshinnekoo","orcid":"0000-0002-2206-1205","position":6,"is_corresponding":false},{"id":28467,"name":"Daniela Bezdan","orcid":"0000-0002-1203-8239","position":7,"is_corresponding":false},{"id":294640,"name":"Michael A. Schmidt","orcid":"0009-0009-9513-8697","position":8,"is_corresponding":false},{"id":294641,"name":"Christopher Mozsary","orcid":"0000-0001-5116-4767","position":9,"is_corresponding":false},{"id":237422,"name":"Ari Melnick","orcid":"0000-0002-8074-2287","position":10,"is_corresponding":false},{"id":294642,"name":"Francine E. Garrett-Bakelman","orcid":"0000-0002-4771-628X","position":11,"is_corresponding":false},{"id":229732,"name":"Brian Crucian","orcid":null,"position":12,"is_corresponding":false},{"id":294643,"name":"Stuart M. C. Lee","orcid":"0000-0001-7065-5182","position":13,"is_corresponding":false},{"id":227770,"name":"Sara R. Zwart","orcid":"0000-0001-8694-0180","position":14,"is_corresponding":false},{"id":227769,"name":"Scott M. Smith","orcid":"0000-0001-9313-7900","position":15,"is_corresponding":false},{"id":227777,"name":"Cem Meydan","orcid":"0000-0002-0663-6216","position":16,"is_corresponding":false},{"id":36370,"name":"Christopher E. Mason","orcid":"0000-0002-1850-1642","position":17,"is_corresponding":false},{"id":296612,"name":"Monica Gertz","orcid":null,"position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T21:06:09.605575Z","pmid":"33242408","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}