{"doi":"10.1016/j.celrep.2020.108331","title":"Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation","abstract":"Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical data showing that higher levels of upper respiratory SLPI correlate both with greater asthma control and the presence of Haemophilus, a bacterial genus associated with AAI. We propose that SLPI could be used as a biomarker of beneficial host-commensal relationships in the airway.","journal":"Cell Reports","year":2020,"id":104352,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":507654,"name":"Ryan McDonough","orcid":null,"position":1,"is_corresponding":false},{"id":506977,"name":"Anne Rosén","orcid":"0000-0002-7656-3382","position":2,"is_corresponding":false},{"id":506978,"name":"Ariel Hernandez-Leyva","orcid":"0000-0003-2427-3727","position":3,"is_corresponding":false},{"id":506979,"name":"Naomi G. Wilson","orcid":"0000-0001-5464-722X","position":4,"is_corresponding":false},{"id":507655,"name":"Michael A. Lint","orcid":null,"position":5,"is_corresponding":false},{"id":308105,"name":"Emilie V. Russler-Germain","orcid":"0000-0002-2036-6697","position":6,"is_corresponding":false},{"id":308102,"name":"Jiani Chai","orcid":"0000-0003-2560-8218","position":7,"is_corresponding":false},{"id":110400,"name":"Leonard B. Bacharier","orcid":"0000-0003-0432-2704","position":8,"is_corresponding":false},{"id":308109,"name":"Chyi‐Song Hsieh","orcid":"0000-0001-5976-9250","position":9,"is_corresponding":false},{"id":19797,"name":"Andrew L. Kau","orcid":"0000-0002-9386-3766","position":10,"is_corresponding":false},{"id":260038,"name":"Natália Jaeger","orcid":"0000-0003-2875-8297","position":0,"is_corresponding":true}],"reference_count":103,"raw_metadata":null,"created_at":"2026-07-18T22:43:22.755723Z","pmid":"33147448","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}