{"doi":"10.1016/j.celrep.2020.108271","title":"GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension","abstract":"Glaucoma is the leading cause of irreversible blindness and is characterized by the death of retinal ganglion cells (RGCs). Recent studies have implicated pro-inflammatory microglia, macrophages, and A1 astrocytes in the pathogenesis of neurodegenerative diseases. The role of pro-inflammatory, neurotoxic A1 astrocytes in glaucoma is just beginning to be explored. Using a mouse model of glaucoma, we demonstrate that ocular hypertension is sufficient to trigger production of C1q, interleukin-1α (IL-1α), and tumor necrosis factor α (TNF-α), three cytokines necessary and sufficient to drive the formation of A1 astrocytes. Upregulation of these cytokines occurs first in CD11b+ CD11c+ cells followed by CD11b+ CD11c− cells. Ablation of this pathway, by either genetic deletions of C1qa, IL-1α, and TNF-α, or treatment with glucagon-like peptide-1 receptor agonist NLY01, reduces A1 astrocyte transformation and RGC death. Together, these results highlight a neuroinflammatory mechanism of glaucomatous neurodegeneration that can be therapeutically targeted by NLY01 administration.","journal":"Cell Reports","year":2020,"id":52169,"datarank":0.7444266945389861,"base_score":4.962844630259907,"endowment":4.962844630259907,"self_citation_contribution":0.7444266945389861,"citation_network_contribution":0.0,"self_endowment_contribution":0.7444266945389861,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":142,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":263078,"name":"Modupe O. Adetunji","orcid":"0000-0002-7698-948X","position":1,"is_corresponding":false},{"id":265233,"name":"Samyuktha Guttha","orcid":null,"position":2,"is_corresponding":false},{"id":265234,"name":"Albert Bargoud","orcid":null,"position":3,"is_corresponding":false},{"id":263079,"name":"Katherine E. Uyhazi","orcid":"0000-0002-4280-1397","position":4,"is_corresponding":false},{"id":263080,"name":"Ahmara G. Ross","orcid":"0000-0002-7527-3121","position":5,"is_corresponding":false},{"id":265235,"name":"Joshua L. Dunaief","orcid":null,"position":6,"is_corresponding":false},{"id":263081,"name":"Qi N. Cui","orcid":"0000-0002-5338-0401","position":7,"is_corresponding":false},{"id":263077,"name":"Jacob Sterling","orcid":"0000-0001-7535-1073","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:42:26.843314Z","pmid":"33147455","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}