{"doi":"10.1016/j.celrep.2020.108151","title":"Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation","abstract":"Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates RB and functions as a collaborative nuclear oncogene. The serine threonine kinase Akt plays a pivotal role in the control of cellular metabolism, survival, and mitogenic signaling. Herein, Akt1-mediated phosphorylation of downstream substrates in the mammary gland is reduced by cyclin D1 genetic deletion and is induced by mammary-gland-targeted cyclin D1 overexpression. Cyclin D1 is associated with Akt1 and augments the rate of onset and maximal cellular Akt1 activity induced by mitogens. Cyclin D1 is identified in a cytoplasmic-membrane-associated pool, and cytoplasmic-membrane-localized cyclin D1-but not nuclear-localized cyclin D1-recapitulates Akt1 transcriptional function. These studies identify a novel extranuclear function of cyclin D1 to enhance proliferative functions via augmenting Akt1 phosphorylation at Ser473.","journal":"Cell Reports","year":2020,"id":81399,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420808,"name":"Xuanmao Jiao","orcid":"0000-0003-4222-9172","position":1,"is_corresponding":false},{"id":421482,"name":"Agnese Di Rocco","orcid":null,"position":2,"is_corresponding":false},{"id":354857,"name":"Duanwen Shen","orcid":null,"position":3,"is_corresponding":false},{"id":420809,"name":"Shaohua Xu","orcid":"0000-0001-9810-1325","position":4,"is_corresponding":false},{"id":362165,"name":"Adam Ertel","orcid":"0000-0001-7455-1559","position":5,"is_corresponding":false},{"id":420810,"name":"Zuoren Yu","orcid":"0000-0003-4196-9662","position":6,"is_corresponding":false},{"id":420811,"name":"Gabriele Di Sante","orcid":"0000-0001-6608-3388","position":7,"is_corresponding":false},{"id":259344,"name":"Min Wang","orcid":"0000-0002-2479-6096","position":8,"is_corresponding":false},{"id":328376,"name":"Zhiping Li","orcid":"0000-0003-1975-8447","position":9,"is_corresponding":false},{"id":421483,"name":"Timothy G. Pestell","orcid":null,"position":10,"is_corresponding":false},{"id":421484,"name":"Mathew C. Casimiro","orcid":null,"position":11,"is_corresponding":false},{"id":420812,"name":"Emmanuel Skordalakes","orcid":"0000-0002-7600-2833","position":12,"is_corresponding":false},{"id":245688,"name":"Samuel Achilefu","orcid":"0000-0002-3133-6717","position":13,"is_corresponding":false},{"id":420813,"name":"Richard G. Pestell","orcid":"0000-0003-3244-8777","position":14,"is_corresponding":false},{"id":420807,"name":"Kexin Chen","orcid":"0000-0003-4248-7681","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-18T21:52:34.401799Z","pmid":"32937140","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}