{"doi":"10.1016/j.celrep.2020.108041","title":"Efficient Strategies for Microglia Replacement in the Central Nervous System","abstract":null,"journal":"Cell Reports","year":2020,"id":591180,"datarank":4.500384693880942,"base_score":5.181783550292085,"endowment":5.181783550292085,"self_citation_contribution":0.7772675325438129,"citation_network_contribution":3.7231171613371297,"self_endowment_contribution":0.7772675325438129,"citer_contribution":3.7231171613371297,"corpus_percentile":null,"corpus_rank":null,"citation_count":177,"citer_count":150,"citers_with_citation_signal":123,"citers_with_endowment":123,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512531,"name":"Yanxia Rao","orcid":null,"position":1,"is_corresponding":false},{"id":1204363,"name":"Yubin Huang","orcid":"0000-0002-7691-9000","position":2,"is_corresponding":false},{"id":779757,"name":"Tian Zhou","orcid":null,"position":3,"is_corresponding":false},{"id":304112,"name":"Rui Feng","orcid":"0000-0003-4151-7228","position":4,"is_corresponding":false},{"id":622810,"name":"Shanshan Xiong","orcid":"0000-0003-1229-4600","position":5,"is_corresponding":false},{"id":1512532,"name":"Ti-Fei Yuan","orcid":null,"position":6,"is_corresponding":false},{"id":211981,"name":"Shan Qin","orcid":null,"position":7,"is_corresponding":false},{"id":1512533,"name":"Yijie Lu","orcid":null,"position":8,"is_corresponding":false},{"id":522182,"name":"Xin Zhou","orcid":"0000-0003-1076-1033","position":9,"is_corresponding":false},{"id":7410,"name":"Xiaoyu Li","orcid":"0009-0006-9840-6704","position":10,"is_corresponding":false},{"id":298438,"name":"Bo Qin","orcid":"0000-0003-2110-6050","position":11,"is_corresponding":false},{"id":197284,"name":"Ying Mao","orcid":null,"position":12,"is_corresponding":false},{"id":568577,"name":"Bo Peng","orcid":"0000-0001-8225-2284","position":13,"is_corresponding":false},{"id":526884,"name":"Zhen Xu","orcid":"0000-0001-8855-0565","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Efficient Strategies for Microglia Replacement in the Central Nervous System","abstract":"Microglia are important immune cells in the central nervous system (CNS). Dysfunctions of gene-deficient microglia contribute to the development and progression of multiple CNS diseases. Microglia replacement by nonself cells has been proposed to treat microglia-associated disorders. However, some attempts have failed due to low replacement efficiency, such as with the traditional bone marrow transplantation approach. In this study, we develop three efficient strategies for microglia replacement: microglia replacement by bone marrow transplantation (mrBMT), microglia replacement by peripheral blood (mrPB), and microglia replacement by microglia transplantation (mrMT). mrBMT and mrPB allow microglia-like cells to efficiently replace resident microglia in the whole CNS. On the other hand, mrMT achieves microglia replacement in brain regions of interest. In summary, the present study offers effective tactics for microglia replacement with diverse application scenarios, which potentially opens up a window on treating microglia-associated CNS disorders.","is_dataset_classified":null,"base_score":5.181783550292085,"endowment":5.181783550292085,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32783928","pmcid":null,"openalex_id":"https://openalex.org/W3048533658","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"","title":null}],"total_grants":1,"fwci":6.0011,"citation_percentile":0.9711591,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2021,"count":18},{"year":2022,"count":22},{"year":2023,"count":29},{"year":2024,"count":43},{"year":2025,"count":37},{"year":2026,"count":26}],"oa_status":"gold","license":"cc-by-sa","oa_locations":[{"url":"https://doi.org/10.1016/j.celrep.2020.108041","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2020.108041","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124720310263?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124720310263?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32783928","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33238120","host_type":"repository"},{"url":"https://doaj.org/article/bdfc4881517246e7b4bb8fb71e74dada","host_type":"repository"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Immune cells in cancer","Neurogenesis and neuroplasticity mechanisms"],"mesh_terms":["Animals","Central Nervous System","Humans","Microglia","Mice"],"keywords":["Microglia","Transplantation","Central nervous system","Neuroscience","Medicine","Immunology","Biology","Inflammation","Internal medicine","Allograft","Allotransplantation","Repopulation","Replacement","Bone Marrow Transplantation","Parabiosis","Fate Mapping","Csf1r"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.27020767.v1","title":"Additional file 1 of Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.27020767","title":"Additional file 1 of Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T14:49:11.171407Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}