{"doi":"10.1016/j.celrep.2020.107949","title":"Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity","abstract":"Long-lived rodents have become an attractive model for the studies on aging. To understand evolutionary paths to long life, we prepare chromosome-level genome assemblies of the two longest-lived rodents, Canadian beaver (Castor canadensis) and naked mole rat (NMR, Heterocephalus glaber), which were scaffolded with in vitro proximity ligation and chromosome conformation capture data and complemented with long-read sequencing. Our comparative genomic analyses reveal that amino acid substitutions at \"disease-causing\" sites are widespread in the rodent genomes and that identical substitutions in long-lived rodents are associated with common adaptive phenotypes, e.g., enhanced resistance to DNA damage and cellular stress. By employing a newly developed substitution model and likelihood ratio test, we find that energy and fatty acid metabolism pathways are enriched for signals of positive selection in both long-lived rodents. Thus, the high-quality genome resource of long-lived rodents can assist in the discovery of genetic factors that control longevity and adaptive evolution.","journal":"Cell Reports","year":2020,"id":94885,"datarank":1.0213346635820362,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.4756967396230783,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.4756967396230783,"corpus_percentile":80.14233774270906,"corpus_rank":2568,"citation_count":37,"citer_count":25,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.619,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":471985,"name":"Qianhui Dou","orcid":"0000-0002-2418-4858","position":1,"is_corresponding":false},{"id":288383,"name":"Guangyi Fan","orcid":"0000-0001-7365-1590","position":2,"is_corresponding":false},{"id":471986,"name":"Quanwei Zhang","orcid":"0000-0002-5849-3368","position":3,"is_corresponding":false},{"id":98158,"name":"Maxwell Sanderford","orcid":"0000-0002-8173-9952","position":4,"is_corresponding":false},{"id":471987,"name":"Alaattin Kaya","orcid":"0000-0002-6132-5197","position":5,"is_corresponding":false},{"id":88699,"name":"Jeremy Johnson","orcid":"0000-0001-8548-5972","position":6,"is_corresponding":false},{"id":96554,"name":"Elinor K. Karlsson","orcid":"0000-0002-4343-3776","position":7,"is_corresponding":false},{"id":218487,"name":"Xiao Tian","orcid":"0000-0001-5300-3596","position":8,"is_corresponding":false},{"id":339644,"name":"Aleksei Mikhalchenko","orcid":"0000-0001-7804-7712","position":9,"is_corresponding":false},{"id":3959,"name":"Sudhir Kumar","orcid":"0000-0002-9918-8212","position":10,"is_corresponding":false},{"id":253604,"name":"Andrei Seluanov","orcid":"0000-0003-3400-538X","position":11,"is_corresponding":false},{"id":18862,"name":"Zhengdong D. Zhang","orcid":"0000-0001-9508-1429","position":12,"is_corresponding":false},{"id":253603,"name":"Vera Gorbunova","orcid":"0000-0001-8979-0333","position":13,"is_corresponding":false},{"id":471988,"name":"Xin Liu","orcid":"0000-0003-3256-2940","position":14,"is_corresponding":false},{"id":218504,"name":"Vadim N. Gladyshev","orcid":"0000-0002-0372-7016","position":15,"is_corresponding":false},{"id":471984,"name":"Xuming Zhou","orcid":"0000-0002-1100-6294","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-18T22:33:00.770265Z","pmid":"32726638","pmcid":"PMC9385191","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}