{"doi":"10.1016/j.celrep.2020.107892","title":"Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation","abstract":"Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with B cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis with inflammation in the central nervous system (CNS). Transcriptomic analysis demonstrates that besides IL-10, Tim-1+ B cells also differentially express a number of co-inhibitory checkpoint receptors including TIGIT. Mice with B cell-specific TIGIT deletion develop spontaneous paralysis with CNS inflammation, but with limited inflammation in other organs. Our findings suggest that Tim-1+ B cells are essential for maintaining self-tolerance and restraining tissue inflammation, and that Tim-1 signaling-dependent TIGIT expression on B cells is essential for maintaining CNS-specific tolerance. A possible critical role of aryl hydrocarbon receptor (AhR) in regulating the B cell function is discussed, as we find that AhR is among the preferentially expressed transcription factors in Tim-1+ B cells and regulates their TIGIT and IL-10 expression.","journal":"Cell Reports","year":2020,"id":60223,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":317635,"name":"Lloyd Bod","orcid":"0000-0003-3663-2571","position":1,"is_corresponding":false},{"id":3256,"name":"Nathalie Pochet","orcid":"0000-0003-1820-5656","position":2,"is_corresponding":false},{"id":319176,"name":"Savithri B. Kota","orcid":null,"position":3,"is_corresponding":false},{"id":317636,"name":"Dan Hu","orcid":"0000-0001-6974-5981","position":4,"is_corresponding":false},{"id":7864,"name":"Asaf Madi","orcid":"0000-0003-3441-3228","position":5,"is_corresponding":false},{"id":319177,"name":"Jessica Kilpatrick","orcid":null,"position":6,"is_corresponding":false},{"id":69334,"name":"Jingwen Shi","orcid":"0000-0002-4802-0727","position":7,"is_corresponding":false},{"id":36948,"name":"Allen W. Ho","orcid":"0000-0002-5861-0552","position":8,"is_corresponding":false},{"id":241907,"name":"Huiyuan Zhang","orcid":"0000-0003-0763-6856","position":9,"is_corresponding":false},{"id":6938,"name":"Raymond A. Sobel","orcid":"0000-0002-0477-9002","position":10,"is_corresponding":false},{"id":7840,"name":"Howard L. Weiner","orcid":"0000-0003-0203-9681","position":11,"is_corresponding":false},{"id":91615,"name":"Terry B. Strom","orcid":null,"position":12,"is_corresponding":false},{"id":18937,"name":"Francisco J. Quintana","orcid":"0000-0001-8156-0736","position":13,"is_corresponding":false},{"id":7860,"name":"Nicole Joller","orcid":"0000-0003-1996-1672","position":14,"is_corresponding":false},{"id":6940,"name":"Vijay K. Kuchroo","orcid":"0000-0001-7177-2110","position":15,"is_corresponding":false},{"id":317634,"name":"Sheng Xiao","orcid":"0000-0001-6458-2490","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T21:08:47.852401Z","pmid":"32668241","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}