{"doi":"10.1016/j.celrep.2020.107841","title":"Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives","abstract":"Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching the inheritance limit of 50% dictated by Mendel's law of gene segregation, making them a promising tool for population engineering. However, current technologies lack control over their propagation capacity, and there are important concerns about potential unchecked spreading. Here, we describe a gene-drive system in Drosophila that generates an analog inheritance output that can be tightly and conditionally controlled to between 50% and 100%. This technology uses a modified SpCas9 that responds to a synthetic, orally available small molecule, fine-tuning the inheritance probability. This system opens a new avenue to feasibility studies for spatial and temporal control of gene drives using small molecules.","journal":"Cell Reports","year":2020,"id":66105,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9489,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":350370,"name":"Brittany S. Leger","orcid":"0000-0002-8467-5472","position":1,"is_corresponding":false},{"id":349798,"name":"Kurt J. Cox","orcid":"0000-0002-8032-3103","position":2,"is_corresponding":false},{"id":352078,"name":"Shubhroz Gill","orcid":null,"position":3,"is_corresponding":false},{"id":285655,"name":"Alena L. Bishop","orcid":"0000-0001-7189-015X","position":4,"is_corresponding":false},{"id":352079,"name":"Garrett D. Scanlon","orcid":null,"position":5,"is_corresponding":false},{"id":350371,"name":"James A. Walker","orcid":"0000-0001-5585-698X","position":6,"is_corresponding":false},{"id":245841,"name":"Valentino M. Gantz","orcid":"0000-0003-2453-0711","position":7,"is_corresponding":false},{"id":275621,"name":"Amit Choudhary","orcid":"0000-0002-8437-0150","position":8,"is_corresponding":false},{"id":285654,"name":"Víctor López Del Amo","orcid":"0000-0002-5567-3072","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-18T21:14:22.090509Z","pmid":"32610142","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}