{"doi":"10.1016/j.celrep.2020.107771","title":"STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice","abstract":"progenitors differentiate efficiently into LTi cells, STING gain-of-function progenitors do not. Furthermore, STING gain-of-function impairs development of all types of ILCs. Patients with STING gain-of-function mutations have fewer ILCs, although they still have lymph nodes. In mice, expression of the STING mutant in RORγT-positive lineages prevents development of lymph nodes and reduces numbers of LTi cells. RORγT lineage-specific expression of STING gain-of-function also causes lung disease. Since RORγT is expressed exclusively in LTi cells during fetal development, our findings suggest that STING gain-of-function prevents lymph node organogenesis by reducing LTi cell numbers in mice.","journal":"Cell Reports","year":2020,"id":96557,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478716,"name":"Carys A. Croft","orcid":"0000-0002-4392-5498","position":1,"is_corresponding":false},{"id":478717,"name":"Teresa L. Ai","orcid":"0000-0001-8376-9285","position":2,"is_corresponding":false},{"id":328043,"name":"Wei Qian","orcid":"0000-0002-2970-5069","position":3,"is_corresponding":false},{"id":330029,"name":"Amber M. Menos","orcid":null,"position":4,"is_corresponding":false},{"id":479946,"name":"Cathrine A. Miner","orcid":null,"position":5,"is_corresponding":false},{"id":479947,"name":"Marie-Louis Frémond","orcid":null,"position":6,"is_corresponding":false},{"id":478718,"name":"Jean‐Marc Doisne","orcid":"0000-0001-6714-1308","position":7,"is_corresponding":false},{"id":283784,"name":"Prabhakar S. Andhey","orcid":null,"position":8,"is_corresponding":false},{"id":328038,"name":"Derek J. Platt","orcid":"0000-0003-0766-4590","position":9,"is_corresponding":false},{"id":249173,"name":"Jennifer K. Bando","orcid":"0000-0002-1331-7424","position":10,"is_corresponding":false},{"id":328042,"name":"Erin R. Wang","orcid":"0000-0002-9163-6316","position":11,"is_corresponding":false},{"id":478719,"name":"Hella Luksch","orcid":"0000-0001-7070-4992","position":12,"is_corresponding":false},{"id":449394,"name":"Thierry Jo Molina","orcid":"0000-0002-3929-9754","position":13,"is_corresponding":false},{"id":478720,"name":"Elisha Roberson","orcid":"0000-0001-5921-2399","position":14,"is_corresponding":false},{"id":52958,"name":"Maxim N. Artyomov","orcid":"0000-0002-1133-4212","position":15,"is_corresponding":false},{"id":478721,"name":"Angela Rösen‐Wolff","orcid":"0000-0002-9613-5879","position":16,"is_corresponding":false},{"id":71132,"name":"Marco Colonna","orcid":"0000-0001-5222-4987","position":17,"is_corresponding":false},{"id":104201,"name":"Frédéric Rieux‐Laucat","orcid":"0000-0001-7858-7866","position":18,"is_corresponding":false},{"id":263550,"name":"James P. Di Santo","orcid":"0000-0002-7146-1862","position":19,"is_corresponding":false},{"id":281907,"name":"Bénédicte Neven","orcid":"0000-0001-8941-0935","position":20,"is_corresponding":false},{"id":328037,"name":"Jonathan J. Miner","orcid":"0000-0001-9551-2962","position":21,"is_corresponding":false},{"id":479945,"name":"Brock G. Bennion","orcid":null,"position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T22:35:06.014648Z","pmid":"32553167","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}