{"doi":"10.1016/j.celrep.2020.107650","title":"Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease","abstract":null,"journal":"Cell Reports","year":2020,"id":634439,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1120809,"name":"Xiaoxia Wu","orcid":"0000-0002-8549-6361","position":1,"is_corresponding":false},{"id":1135219,"name":"Xiaoming Li","orcid":"0000-0001-6024-4347","position":2,"is_corresponding":false},{"id":897578,"name":"Ming Li","orcid":"0000-0001-6665-8559","position":3,"is_corresponding":false},{"id":451814,"name":"Fang Li","orcid":"0000-0002-2188-3397","position":4,"is_corresponding":false},{"id":1645467,"name":"Lingxia Wang","orcid":null,"position":5,"is_corresponding":false},{"id":627648,"name":"Xixi Zhang","orcid":"0000-0001-5241-6356","position":6,"is_corresponding":false},{"id":292241,"name":"Yue Zhang","orcid":"0000-0003-1456-9866","position":7,"is_corresponding":false},{"id":1402056,"name":"Yan Luo","orcid":"0000-0001-9282-3212","position":8,"is_corresponding":false},{"id":486386,"name":"Hui Wang","orcid":"0000-0002-0011-8899","position":9,"is_corresponding":false},{"id":1645468,"name":"Yiguo Jiang","orcid":null,"position":10,"is_corresponding":false},{"id":1517020,"name":"Haibing Zhang","orcid":"0000-0002-8814-7378","position":11,"is_corresponding":false},{"id":1457872,"name":"Haiwei Zhang","orcid":"0000-0002-0398-7926","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease","abstract":"Receptor-interacting protein kinase 3 (RIPK3) has been identified as an essential regulator of necroptosis, apoptosis, and inflammatory signaling. RIPK3 contains an N-terminal kinase domain and a C-terminal RIP homotypic interaction motif (RHIM). However, the physiological roles of RIPK3 RHIM remain unclear. Here we generate knockin mice endogenously expressing the RIPK3 RHIM mutant, RIPK3 V448P . Cells expressing RIPK3 V448P are resistant to RIPK1 kinase-dependent apoptosis and necroptosis, and Ripk3 V448P/V448P mice rescue embryonic lethality of Fadd -deficient mice by intercrossing. Strikingly, Ripk3 V448P/V448P Fadd −/− mice display more severe lymphoproliferative disease with a marked increase in abnormal CD3 + B220 + lymphocytes compared with Ripk3 −/− Fadd −/− mice. More importantly, these inflammatory morbidities in Ripk3 V448P/V448P Fadd −/− mice are profoundly inhibited by additional deletion of Ripk1 . Taken together, these results reveal a previously unidentified physiological function of RHIM of RIPK3 in regulating RIPK1-dependent cell death and lymphoproliferative disease.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32433959","pmcid":null,"openalex_id":"https://openalex.org/W3026701216","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"31771537","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31970688","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2016YFC1304900","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2018YFC1200201","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"Ripk3V448P/+Ripk1","title":null},{"funder_name":"Harvard Medical School","grant_id":"S166","title":null},{"funder_name":"University of California, Los Angeles","grant_id":"","title":null}],"total_grants":7,"fwci":1.0437,"citation_percentile":0.74777391,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":7},{"year":2023,"count":5},{"year":2024,"count":7},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2211124720306033/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124720306033/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124720306033?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124720306033?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2020.107650","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32433959","host_type":"repository"},{"url":"https://doaj.org/article/b3b2b77b28b94f17bb6e84d1f0f67bbf","host_type":"repository"}],"fields_of_study":["Cell death mechanisms and regulation","Phagocytosis and Immune Regulation","interferon and immune responses","Animals","Cell Death","Lymphoproliferative Disorders","Mice","Receptor-Interacting Protein Serine-Threonine Kinases"],"mesh_terms":["Animals","Lymphoproliferative Disorders","Cell Death","Mice","Receptor-Interacting Protein Serine-Threonine Kinases"],"keywords":["RIPK1","Necroptosis","FADD","Programmed cell death","Cell biology","Kinase","Biology","Protein kinase domain","Cancer research","Apoptosis","Caspase","Mutant","Biochemistry","Embryonic development","Inflammation","Lymphoproliferative Disease","Mlkl","Ripk3","Rhim","Receptor-interacting Protein Homotypic Interaction Motifs"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:40:21.682298Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}