{"doi":"10.1016/j.celrep.2020.107629","title":"S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression","abstract":"Many proteins that are needed for progression through S-phase are produced from transcripts that peak in the S-phase, linking temporal expression of those proteins to the time that they are required in cell cycle. Here, we explore the potential roles of long non-coding RNAs in cell cycle progression. We use a sensitive click-chemistry approach to isolate nascent RNAs in a human cell line, and we identify more than 900 long non-coding RNAs (lncRNAs) whose synthesis peaks during the S-phase. More than 200 of these are long intergenic non-coding RNAs (lincRNAs) with S-phase-specific expression. We characterize three of these lincRNAs by knockdown and find that all three lincRNAs are required for appropriate S-phase progression. We infer that non-coding RNAs are key regulatory effectors during the cell cycle, acting on distinct regulatory networks, and herein, we provide a large catalog of candidate cell-cycle regulatory RNAs.","journal":"Cell Reports","year":2020,"id":69076,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":366273,"name":"Enver Çagrı Izgü","orcid":"0000-0001-6673-3635","position":1,"is_corresponding":false},{"id":366274,"name":"Manashree Damle","orcid":"0000-0002-7295-508X","position":2,"is_corresponding":false},{"id":367853,"name":"Vladislava Chalei","orcid":null,"position":3,"is_corresponding":false},{"id":339728,"name":"Fei Ji","orcid":"0000-0002-7120-3812","position":4,"is_corresponding":false},{"id":260528,"name":"Ruslan I. Sadreyev","orcid":"0000-0002-4240-5466","position":5,"is_corresponding":false},{"id":366275,"name":"Jack W. Szostak","orcid":"0000-0003-4131-1203","position":6,"is_corresponding":false},{"id":23407,"name":"Robert E. Kingston","orcid":"0000-0003-3628-4335","position":7,"is_corresponding":false},{"id":366272,"name":"Özlem Yıldırım","orcid":"0000-0003-1018-0335","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-18T21:42:22.705573Z","pmid":"32402276","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}