{"doi":"10.1016/j.celrep.2020.107622","title":"A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury","abstract":"To date, no stem cell therapy has been directed to specific recipients-and, conversely, withheld from others-based on a clinical or molecular profile congruent with that cell's therapeutic mechanism-of-action (MOA) for that condition. We address this challenge preclinically with a prototypical scenario: human neural stem cells (hNSCs) against perinatal/neonatal cerebral hypoxic-ischemic injury (HII). We demonstrate that a clinically translatable magnetic resonance imaging (MRI) algorithm, hierarchical region splitting, provides a rigorous, expeditious, prospective, noninvasive \"biomarker\" for identifying subjects with lesions bearing a molecular profile indicative of responsiveness to hNSCs' neuroprotective MOA. Implanted hNSCs improve lesional, motor, and/or cognitive outcomes only when there is an MRI-measurable penumbra that can be forestalled from evolving into necrotic core; the core never improves. Unlike the core, a penumbra is characterized by a molecular profile associated with salvageability. Hence, only lesions characterized by penumbral > core volumes should be treated with cells, making such measurements arguably a regenerative medicine selection biomarker.","journal":"Cell Reports","year":2020,"id":89020,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":450885,"name":"Neal H. Nathan","orcid":"0000-0003-2017-9418","position":1,"is_corresponding":false},{"id":450886,"name":"Nirmalya Ghosh","orcid":"0000-0002-8580-2541","position":2,"is_corresponding":false},{"id":55774,"name":"Cameron D. Pernia","orcid":null,"position":3,"is_corresponding":false},{"id":450887,"name":"Janessa B. Law","orcid":"0000-0002-6279-1528","position":4,"is_corresponding":false},{"id":452025,"name":"Ruslan Nuryyev","orcid":null,"position":5,"is_corresponding":false},{"id":452026,"name":"Amy Plaia","orcid":null,"position":6,"is_corresponding":false},{"id":452027,"name":"Alena Yusof","orcid":null,"position":7,"is_corresponding":false},{"id":452028,"name":"Beatriz Tone","orcid":null,"position":8,"is_corresponding":false},{"id":450888,"name":"Melissa S. Dulcich","orcid":"0000-0003-4177-2317","position":9,"is_corresponding":false},{"id":450889,"name":"Dustin R. Wakeman","orcid":"0000-0002-7873-1546","position":10,"is_corresponding":false},{"id":452029,"name":"Nejmi Dilmac","orcid":null,"position":11,"is_corresponding":false},{"id":452030,"name":"Walter D. Niles","orcid":null,"position":12,"is_corresponding":false},{"id":450890,"name":"Richard L. Sidman","orcid":"0000-0002-7863-659X","position":13,"is_corresponding":false},{"id":338066,"name":"André Obenaus","orcid":null,"position":14,"is_corresponding":false},{"id":315745,"name":"Evan Y. Snyder","orcid":null,"position":15,"is_corresponding":false},{"id":342792,"name":"Stephen Ashwal","orcid":"0000-0003-1947-0574","position":16,"is_corresponding":false},{"id":450884,"name":"Richard E. Hartman","orcid":"0000-0001-9235-3169","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-18T22:01:50.225871Z","pmid":"32402283","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}