{"doi":"10.1016/j.celrep.2020.107524","title":"Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation","abstract":"Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia, the gateway for tumor development. In a wide range of tissues, this occurs primarily through enhanced effects on cellular proliferation. Whether additional mechanisms contribute to β-catenin-driven hyperplasia remains unknown. The adrenal cortex is an ideal system in which to explore this question, as it undergoes hyperplasia following somatic β-catenin gain-of-function (βcat-GOF) mutations. Targeting βcat-GOF to zona Glomerulosa (zG) cells leads to a progressive hyperplastic expansion in the absence of increased proliferation. Instead, we find that hyperplasia results from a functional block in the ability of zG cells to transdifferentiate into zona Fasciculata (zF) cells. Mechanistically, zG cells demonstrate an upregulation of Pde2a, an inhibitor of zF-specific cAMP/PKA signaling. Hyperplasia is further exacerbated by trophic factor stimulation leading to organomegaly. Together, these data indicate that β-catenin drives adrenal hyperplasia through both proliferation-dependent and -independent mechanisms.","journal":"Cell Reports","year":2020,"id":59004,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":69,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310371,"name":"Sining Leng","orcid":"0000-0002-6308-493X","position":1,"is_corresponding":false},{"id":310372,"name":"Yixing Yuchi","orcid":"0000-0002-9439-0913","position":2,"is_corresponding":false},{"id":310373,"name":"Kleiton Silva Borges","orcid":"0000-0003-0356-922X","position":3,"is_corresponding":false},{"id":310374,"name":"Nick A. Guagliardo","orcid":"0000-0003-2539-1346","position":4,"is_corresponding":false},{"id":312724,"name":"Manasvi S. Shah","orcid":null,"position":5,"is_corresponding":false},{"id":310375,"name":"Gerard Ruiz‐Babot","orcid":"0000-0002-8322-3159","position":6,"is_corresponding":false},{"id":310376,"name":"Dulanjalee Kariyawasam","orcid":"0000-0002-3870-202X","position":7,"is_corresponding":false},{"id":32746,"name":"Makoto M. Taketo","orcid":"0000-0002-9032-4505","position":8,"is_corresponding":false},{"id":310377,"name":"Ji Miao","orcid":"0000-0003-0869-4492","position":9,"is_corresponding":false},{"id":310378,"name":"Paula Q. Barrett","orcid":"0000-0003-2052-3899","position":10,"is_corresponding":false},{"id":310379,"name":"Diana L. Carlone","orcid":"0000-0001-6935-0189","position":11,"is_corresponding":false},{"id":253830,"name":"David T. Breault","orcid":"0000-0002-0402-4857","position":12,"is_corresponding":false},{"id":310370,"name":"Emanuele Pignatti","orcid":"0000-0002-5372-5692","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32320669","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}