{"doi":"10.1016/j.celrep.2020.02.025","title":"β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia","abstract":"Alzheimer's disease is the world's most common neurodegenerative disorder. It is associated with neuroinflammation involving activation of microglia by β-amyloid (Aβ) deposits. Based on previous studies showing apoptosis-associated speck-like protein containing a CARD (ASC) binding and cross-seeding extracellular Aβ, we investigate the propagation of ASC between primary microglia and the effects of ASC-Aβ composites on microglial inflammasomes and function. Indeed, ASC released by a pyroptotic cell can be functionally built into the neighboring microglia NOD-like receptor protein (NLRP3) inflammasome. Compared with protein-only application, exposure to ASC-Aβ composites amplifies the proinflammatory response, resulting in pyroptotic cell death, setting free functional ASC and inducing a feedforward stimulating vicious cycle. Clustering around ASC fibrils also compromises clearance of Aβ by microglia. Together, these data enable a closer look at the turning point from acute to chronic Aβ-related neuroinflammation through formation of ASC-Aβ composites.","journal":"Cell Reports","year":2020,"id":50367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":196,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9633,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":247303,"name":"Hannah Scheiblich","orcid":"0000-0003-1542-401X","position":1,"is_corresponding":false},{"id":247304,"name":"Inga V. Hochheiser","orcid":"0000-0001-6649-2624","position":2,"is_corresponding":false},{"id":248803,"name":"Rebecca Brinkschulte","orcid":null,"position":3,"is_corresponding":false},{"id":247305,"name":"Dietmar Riedel","orcid":"0000-0003-2970-6894","position":4,"is_corresponding":false},{"id":104390,"name":"Eicke Latz","orcid":"0000-0003-1488-5666","position":5,"is_corresponding":false},{"id":19172,"name":"Matthias Geyer","orcid":"0000-0002-7718-5002","position":6,"is_corresponding":false},{"id":225475,"name":"Michael T. Heneka","orcid":"0000-0003-4996-1630","position":7,"is_corresponding":false},{"id":248802,"name":"Lea L. Friker","orcid":null,"position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-18T20:38:25.860949Z","pmid":"32187546","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}