{"doi":"10.1016/j.celrep.2019.12.073","title":"Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation","abstract":"Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activation of MAPK signaling. However, the regulatory mechanisms underlying this kinase-dependent cytokine production remain poorly understood. In the present study, we establish that the kinase activity of RIPK1/3 regulates cytokine translation in mouse and human macrophages. Furthermore, we show that this inflammatory response is downregulated by type I interferon (IFN) signaling, independent of type I IFN-promoted cell death. Specifically, low-level constitutive IFN signaling attenuates RIPK-driven activation of cap-dependent translation initiation pathway components AKT, mTORC1, 4E-BP and eIF4E, while promoting RIPK-dependent cell death. Altogether, these data characterize constitutive IFN signaling as a regulator of RIPK-dependent inflammation and establish cap-dependent translation as a crucial checkpoint in the regulation of cytokine production.","journal":"Cell Reports","year":2020,"id":96292,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478234,"name":"Joseph Sarhan","orcid":null,"position":1,"is_corresponding":false},{"id":477445,"name":"Beiyun C. Liu","orcid":"0000-0001-5598-9774","position":2,"is_corresponding":false},{"id":478235,"name":"Wilson M. Connolly","orcid":null,"position":3,"is_corresponding":false},{"id":477446,"name":"Stephen A. Schworer","orcid":"0000-0001-7741-8972","position":4,"is_corresponding":false},{"id":51938,"name":"Irina Smirnova","orcid":null,"position":5,"is_corresponding":false},{"id":477447,"name":"Amy Y. Tang","orcid":"0000-0003-4429-7152","position":6,"is_corresponding":false},{"id":477448,"name":"Vladimir Ilyukha","orcid":"0000-0002-2371-1740","position":7,"is_corresponding":false},{"id":478236,"name":"Jodie Pietruska","orcid":null,"position":8,"is_corresponding":false},{"id":477449,"name":"Soroush Tahmasebi","orcid":"0000-0002-2807-5480","position":9,"is_corresponding":false},{"id":17875,"name":"Nahum Sonenberg","orcid":"0000-0002-4707-8759","position":10,"is_corresponding":false},{"id":289978,"name":"Alexei Degterev","orcid":"0000-0002-8240-7132","position":11,"is_corresponding":false},{"id":51936,"name":"Alexander Poltorak","orcid":"0000-0002-5375-6587","position":12,"is_corresponding":false},{"id":388580,"name":"Hayley I. Muendlein","orcid":"0000-0003-3006-5780","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"31968247","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}