{"doi":"10.1016/j.celrep.2019.07.075","title":"Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability","abstract":null,"journal":"Cell Reports","year":2019,"id":686907,"datarank":0.6435689161722588,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":0.0,"self_endowment_contribution":0.6435689161722588,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1794538,"name":"Rima-Marie Wazen","orcid":null,"position":1,"is_corresponding":false},{"id":1055870,"name":"Pina Colarusso","orcid":"0000-0002-2875-3579","position":2,"is_corresponding":false},{"id":315322,"name":"S.R. Wayne Chen","orcid":"0000-0001-5808-0304","position":3,"is_corresponding":false},{"id":511322,"name":"Gerald W. Zamponi","orcid":"0000-0002-0644-9066","position":4,"is_corresponding":false},{"id":315321,"name":"Ray W. Turner","orcid":"0000-0002-7898-2409","position":5,"is_corresponding":false},{"id":1794537,"name":"Giriraj Sahu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability","abstract":"The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). We used super-resolution and FRET microscopy to investigate the proximity and functional coupling among Cav1.3/Cav1.2, RyR2, and KCa3.1 potassium channels that contribute to the sAHP. dSTORM and FRET imaging shows that Cav1.3, RyR2, and KCa3.1 are organized as a triprotein complex that colocalizes with junctophilin (JPH) 3 and 4 proteins that tether the plasma membrane to the endoplasmic reticulum. JPH3 and JPH4 shRNAs dissociated a Cav1.3-RyR2-KCa3.1 complex and reduced the IsAHP. Infusing JPH3 and JPH4 antibodies into CA1 cells reduced IsAHP and spike accommodation. These data indicate that JPH3 and JPH4 proteins maintain a Cav1-RyR2-KCa3.1 complex that allows two calcium sources to act in tandem to define the activation properties of KCa3.1 channels and the IsAHP.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31461656","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"unidentified","title":"unidentified"},{"funder_name":"CIHR","grant_id":"","title":null},{"funder_name":"Natural Sciences and Engineering Research Council of Canada","grant_id":"","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"","title":null},{"funder_name":"CIHR","grant_id":"","title":null}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2211124719309799/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124719309799?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124719309799?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doaj.org/article/dc84eac3b1d4469582aff646ffab951d","host_type":"repository"},{"url":"https://doi.org/10.1016/j.celrep.2019.07.075","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/31461656","host_type":""},{"url":"https://dx.doi.org/10.1016/j.celrep.2019.07.075","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences","Action Potentials","Animals","CA1 Region, Hippocampal","Calcium Channels, L-Type","Cell Line","Cell Membrane","Cells, Cultured","Endoplasmic Reticulum","Female","Humans","Intermediate-Conductance Calcium-Activated Potassium Channels","Male","Membrane Proteins","Mice","Neurons","Rats","Rats, Sprague-Dawley","Ryanodine Receptor Calcium Release Channel"],"mesh_terms":["Neurons","Cells, Cultured","Cell Line","Cell Membrane","Endoplasmic Reticulum","Animals","Humans","Mice","Rats","Rats, Sprague-Dawley","Calcium Channels, L-Type","Ryanodine Receptor Calcium Release Channel","Membrane Proteins","Action Potentials","Female","Male","Intermediate-Conductance Calcium-Activated Potassium Channels","CA1 Region, Hippocampal"],"keywords":["Hippocampus","Ryanodine receptor","FRET","Sahp","Kca3.1","Ryr2","Dstorm","Junctophilin","Cav1.2","Ca(v)1.3","Male","Neurons","Calcium Channels, L-Type","QH301-705.5","Cell Membrane","Action Potentials","Membrane Proteins","Ryanodine Receptor Calcium Release Channel","Endoplasmic Reticulum","Intermediate-Conductance Calcium-Activated Potassium Channels","Cell Line","Rats","Rats, Sprague-Dawley","Mice","Animals","Humans","Female","Biology (General)","CA1 Region, Hippocampal","Cells, Cultured"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:47:07.692986Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}