{"doi":"10.1016/j.celrep.2019.03.039","title":"The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization","abstract":null,"journal":"Cell Reports","year":2019,"id":602813,"datarank":0.5333022092234121,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.0,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":294228,"name":"Yuhe R. Yang","orcid":"0000-0003-2321-4653","position":1,"is_corresponding":false},{"id":257573,"name":"Karen Tran","orcid":"0000-0002-4393-2073","position":2,"is_corresponding":false},{"id":148367,"name":"Yimeng Wang","orcid":null,"position":3,"is_corresponding":false},{"id":450568,"name":"Chi-I Chiang","orcid":null,"position":4,"is_corresponding":false},{"id":230741,"name":"Gabriel Ozorowski","orcid":"0000-0002-9695-8138","position":5,"is_corresponding":false},{"id":327657,"name":"Yongli Xiao","orcid":null,"position":6,"is_corresponding":false},{"id":230082,"name":"Andrew B. Ward","orcid":"0000-0001-7153-3769","position":7,"is_corresponding":false},{"id":257578,"name":"Richard T. Wyatt","orcid":"0000-0001-7085-1351","position":8,"is_corresponding":false},{"id":449696,"name":"Yuxing Li","orcid":"0000-0001-9785-2960","position":9,"is_corresponding":false},{"id":257250,"name":"Lin Lei","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization","abstract":"Despite recent progress in engineering native trimeric HIV-1 envelope glycoprotein (Env) mimics as vaccine candidates, Env trimers often induce vaccine-matched neutralizing antibody (NAb) responses. Understanding the specificities of autologous NAb responses and the underlying molecular mechanisms restricting the neutralization breadth is therefore informative to improve vaccine efficacy. Here, we delineate the response specificity by single B cell sorting and serum analysis of guinea pigs immunized with BG505 SOSIP.664 Env trimers. Our results reveal a prominent immune target containing both conserved and strain-specific residues in the C3/V4 region of Env in trimer-vaccinated animals. The defined NAb response shares a high degree of similarity with the early NAb response developed by a naturally infected infant from whom the HIV virus strain BG505 was isolated and later developed a broadly NAb response. Our study describes strain-specific responses and their possible evolution pathways, thereby highlighting the potential to broaden NAb responses by immunogen re-design.","is_dataset_classified":null,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30970260","pmcid":"PMC6458978","openalex_id":"https://openalex.org/W2938507738","authors":[],"funders":[{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"P01AI104722","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"R01AI102766","title":null},{"funder_name":"National Institute of Allergy and Infectious Diseases","grant_id":"UM1AI100663","title":null},{"funder_name":"Bill and Melinda Gates Foundation","grant_id":"OPP1084519","title":null},{"funder_name":"Bill and Melinda Gates Foundation","grant_id":"OPP1115782","title":null},{"funder_name":"Ministerie van Buitenlandse Zaken","grant_id":"BG505.W6M.ENV.C2","title":null},{"funder_name":"Ministerie van Buitenlandse Zaken","grant_id":"HIV-1 BG505","title":null},{"funder_name":"Ministerie van Buitenlandse Zaken","grant_id":"MG505.W0M.ENV.A2","title":null},{"funder_name":"Ministerie van Buitenlandse Zaken","grant_id":"PGT121","title":null},{"funder_name":"Ministerie van Buitenlandse Zaken","grant_id":"PGT151","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"P30 AI036214","title":null},{"funder_name":"NCATS NIH HHS","grant_id":"UL1 TR001442","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI136756","title":null},{"funder_name":"National Institutes of Health","grant_id":"5P01AI104722-04","title":"High Resolution Analysis of Env-directed B Cells to Accelerate Vaccine Design"},{"funder_name":"National Institutes of Health","grant_id":"3UM1AI100663-04S1","title":"Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery"},{"funder_name":"National Institutes of Health","grant_id":"5R01AI102766-05","title":"High-resolution definition of B cell responses to HIV Env for immunogen design"},{"funder_name":"United States Agency for International Development","grant_id":"","title":null},{"funder_name":"National Institutes of Health","grant_id":"","title":null},{"funder_name":"International AIDS Vaccine Initiative","grant_id":"","title":null}],"total_grants":19,"fwci":3.5239,"citation_percentile":0.93942175,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":11},{"year":2021,"count":10},{"year":2022,"count":6},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2211124719303559/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124719303559/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124719303559?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124719303559?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2019.03.039","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30970260","host_type":"repository"},{"url":"https://doaj.org/article/cd35540b9b3146f085f6db86ae7701bc","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6458978","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6458978","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6458978?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1016/j.celrep.2019.03.039","host_type":""},{"url":"https://dx.doi.org/10.1016/j.celrep.2019.03.039","host_type":""}],"fields_of_study":["HIV Research and Treatment","T-cell and B-cell Immunology","vaccines and immunoinformatics approaches","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Epitopes","Glycoproteins","Guinea Pigs","HIV-1","Humans","Immunization","env Gene Products, Human Immunodeficiency Virus"],"mesh_terms":["Animals","Epitopes","Glycoproteins","Guinea Pigs","Humans","Immunization","HIV-1","env Gene Products, Human Immunodeficiency Virus"],"keywords":["Immunogen","Epitope","Neutralization","Virology","Glycoprotein","Immunization","Biology","Antibody","Immune system","Viral envelope","AIDS Vaccines","Immunology","Vaccination","Virus","Genetics","Vaccine trial","Monoclonal antibody","QH301-705.5","Guinea Pigs","env Gene Products, Human Immunodeficiency Virus","Article","Epitopes","HIV-1","Animals","Humans","Biology (General)","Glycoproteins"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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