{"doi":"10.1016/j.celrep.2018.11.008","title":"Sustained Melanopsin Photoresponse Is Supported by Specific Roles of β-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment","abstract":null,"journal":"Cell Reports","year":2018,"id":672413,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1756843,"name":"Megumi Hatori","orcid":null,"position":1,"is_corresponding":false},{"id":466291,"name":"Kiersten Ruda","orcid":"0000-0003-2744-6267","position":2,"is_corresponding":false},{"id":873763,"name":"Giorgia Benegiamo","orcid":"0000-0001-7164-6771","position":3,"is_corresponding":false},{"id":1756845,"name":"James Demas","orcid":null,"position":4,"is_corresponding":false},{"id":407408,"name":"Satchidananda Panda","orcid":"0000-0002-7855-0091","position":5,"is_corresponding":false},{"id":567397,"name":"Ludovic S. 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This forms a binding site for β-arrestin 1 (βARR1) and β-arrestin 2. β-arrestin 2 primarily regulates the deactivation of melanopsin; accordingly, βαrr2 −/− mice exhibit prolonged ipRGC responses after cessation of a light pulse. β-arrestin 1 primes melanopsin for regeneration. Therefore, βαrr1 −/− ipRGCs become desensitized after repeated or prolonged photostimulation. The lack of either β-arrestin attenuates ipRGC response under prolonged illumination, suggesting that β-arrestin 2-mediated deactivation and β-arrestin 1-dependent regeneration of melanopsin function in sequence. In conclusion, we discovered a molecular mechanism by which β-arrestins regulate different aspects of melanopsin photoresponses and allow ipRGC-sustained responses under prolonged illumination.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30485815","pmcid":"PMC6396282","openalex_id":"https://openalex.org/W2902118379","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"EY 016807","title":null},{"funder_name":"National Institutes of Health","grant_id":"NS066457","title":null},{"funder_name":"National Institutes of Health","grant_id":"S10 RR027450","title":null},{"funder_name":"Glenn Foundation for Medical Research","grant_id":"P30 CA014195","title":null},{"funder_name":"Glenn Foundation for Medical Research","grant_id":"P30 EY019005","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R21 NS066457","title":null},{"funder_name":"NEI NIH HHS","grant_id":"R01 EY016807","title":null},{"funder_name":"National Institutes of Health","grant_id":"1S10RR027450-01","title":"Automated high-throughput analysis system"},{"funder_name":"National Institutes of Health","grant_id":"2P30CA014195-31","title":"Senior Leadership"},{"funder_name":"National Institutes of Health","grant_id":"1R21NS066457-01","title":"Melanopsin Photoactivation Assay"},{"funder_name":"National Institutes of Health","grant_id":"5P30EY019005-09","title":"Core Grant for Vision Research"},{"funder_name":"National Institutes of Health","grant_id":"5R01EY016807-03","title":"Circadian Photoentrainment in Mammals"},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"","title":null},{"funder_name":"Leona M. and Harry B. 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