{"doi":"10.1016/j.celrep.2017.10.116","title":"Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy","abstract":null,"journal":"Cell Reports","year":2017,"id":662071,"datarank":0.6284482113039639,"base_score":4.189654742026425,"endowment":4.189654742026425,"self_citation_contribution":0.6284482113039639,"citation_network_contribution":0.0,"self_endowment_contribution":0.6284482113039639,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":382967,"name":"Xiling Li","orcid":"0000-0002-2727-244X","position":1,"is_corresponding":false},{"id":382968,"name":"Dion Dickman","orcid":"0000-0003-1884-284X","position":2,"is_corresponding":false},{"id":382965,"name":"Pragya Goel","orcid":"0000-0002-6348-4909","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy","abstract":"Retrograde signaling systems are fundamental modes of communication synapses utilize to dynamically and adaptively modulate activity. However, the inductive mechanisms that gate retrograde communication in the postsynaptic compartment remain enigmatic. We have investigated retrograde signaling at the Drosophila neuromuscular junction, where three seemingly disparate perturbations to the postsynaptic cell trigger a similar enhancement in presynaptic neurotransmitter release. We show that the same presynaptic genetic machinery and enhancements in active zone structure are utilized by each inductive pathway. However, all three induction mechanisms differ in temporal, translational, and CamKII activity requirements to initiate retrograde signaling in the postsynaptic cell. Intriguingly, pharmacological blockade of postsynaptic glutamate receptors, and not calcium influx through these receptors, is necessary and sufficient to induce rapid retrograde homeostatic signaling through CamKII. Thus, three distinct induction mechanisms converge on the same retrograde signaling system to drive the homeostatic strengthening of presynaptic neurotransmitter release.","is_dataset_classified":null,"base_score":4.189654742026425,"endowment":4.189654742026425,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29186673","pmcid":"PMC5728443","openalex_id":"https://openalex.org/W2769372080","authors":[],"funders":[{"funder_name":"NIH","grant_id":"NS091546","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS091546","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01NS091546-02","title":"Molecular Mechanisms Governing the Homeostatic Control of Synaptic Strength"},{"funder_name":"Ellison Medical Foundation","grant_id":"","title":null},{"funder_name":"Klingenstein-Simons Foundation","grant_id":"","title":null},{"funder_name":"Alfred P. Sloan Foundation","grant_id":"","title":null},{"funder_name":"Whitehall Foundation","grant_id":"","title":null},{"funder_name":"Mallinckrodt Foundation","grant_id":"","title":null},{"funder_name":"USC","grant_id":"","title":null}],"total_grants":9,"fwci":3.7146,"citation_percentile":0.94790365,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":11},{"year":2019,"count":11},{"year":2020,"count":10},{"year":2021,"count":4},{"year":2022,"count":8},{"year":2023,"count":8},{"year":2024,"count":4},{"year":2025,"count":6},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2211124717315966/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124717315966/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124717315966?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124717315966?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2017.10.116","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29186673","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5728443","host_type":"repository"},{"url":"https://doaj.org/article/308bb3b530684540b72994ac46614cfe","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.celrep.2017.10.116","host_type":""}],"fields_of_study":["Neurobiology and Insect Physiology Research","Genetics, Aging, and Longevity in Model Organisms","Plant and Biological Electrophysiology Studies","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Calcium-Calmodulin-Dependent Protein Kinase Type 2","Drosophila","Drosophila Proteins","Excitatory Postsynaptic Potentials","Neuromuscular Junction","Neuronal Plasticity","Presynaptic Terminals","Receptors, Glutamate","Signal Transduction","Synapses","Synaptic Transmission"],"mesh_terms":["Animals","Drosophila","Synaptic Transmission","Neuromuscular Junction","Neuronal Plasticity","Synapses","Signal Transduction","Receptors, Glutamate","Presynaptic Terminals","Excitatory Postsynaptic Potentials","Drosophila Proteins","Calcium-Calmodulin-Dependent Protein Kinase Type 2"],"keywords":["Retrograde signaling","Postsynaptic potential","Neuroscience","Active zone","Postsynaptic density","Glutamate receptor","Neurotransmitter receptor","Biology","Neurotransmitter","Cell biology","Signal transduction","Neuromuscular junction","Receptor","Central nervous system","Synaptic vesicle","Biochemistry","Drosophila","Synaptic plasticity","Homeostasis","Neuronal Plasticity","QH301-705.5","Presynaptic Terminals","Excitatory Postsynaptic Potentials","Synaptic Transmission","Receptors, Glutamate","Synapses","Animals","Drosophila Proteins","Biology (General)","Calcium-Calmodulin-Dependent Protein Kinase Type 2"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T12:23:08.437808Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}