{"doi":"10.1016/j.celrep.2017.02.031","title":"Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment","abstract":null,"journal":"Cell Reports","year":2017,"id":16493,"datarank":0.7677823097490961,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.3184224687159975,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.3184224687159975,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":18,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":121537,"name":"Vincent Frappier","orcid":null,"position":1,"is_corresponding":false},{"id":15336,"name":"Alison E. Ringel","orcid":"0000-0002-6451-9376","position":2,"is_corresponding":false},{"id":48095,"name":"Cynthia Wolberger","orcid":"0000-0001-8578-2969","position":3,"is_corresponding":false},{"id":115317,"name":"Leonard Guarente","orcid":null,"position":4,"is_corresponding":false},{"id":121536,"name":"Caitlin R. Ondracek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28273448","pmcid":"PMC5407064","openalex_id":"https://openalex.org/W2594117778","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"R01 AG021150","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG015339","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R56 AG015339","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG011119","title":null},{"funder_name":"NIH","grant_id":"","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"","title":null},{"funder_name":"Glenn Foundation for Medical Research","grant_id":"","title":null}],"total_grants":7,"fwci":1.195,"citation_percentile":0.76969851,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2020,"count":6},{"year":2021,"count":2},{"year":2022,"count":2},{"year":2024,"count":4},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2211124717302127/pdf","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2017.02.031","host_type":"GOLD"},{"url":"http://www.cell.com/article/S2211124717302127/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124717302127?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124717302127?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28273448","host_type":"repository"},{"url":"https://doaj.org/article/1d252bad54af4c79b5877aa6ce62fb6a","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5407064","host_type":"repository"}],"fields_of_study":["Sirtuins and Resveratrol in Medicine","Autophagy in Disease and Therapy","Adipose Tissue and Metabolism","Medicine","Biology","Chemistry","Acetylation","Humans","Kinetics","Models, Molecular","Mutation","NAD","Protein Stability","Saccharomyces cerevisiae","Sequence Homology, Amino Acid","Sirtuin 2","Substrate Specificity"],"mesh_terms":["Acetylation","Humans","Kinetics","Models, Molecular","Mutation","NAD","Saccharomyces cerevisiae","Substrate Specificity","Sequence Homology, Amino Acid","Protein Stability","Sirtuin 2"],"keywords":["NAD+ kinase","Sirtuin","Mutant","Enzyme","Acetylation","Yeast","SIRT2","Biology","Function (biology)","Mutation","Sirtuin 1","Cell biology","Saccharomyces cerevisiae","Biochemistry","Genetics","Gene","Downregulation and upregulation","Aging","Sir2","SIRT1","Nad(+)","Adaptive Mutations","Kinetic Analyses","Predictive Protein Modeling","Yeast Replicative Lifespan"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Responsible consumption and production"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.14634182.v1","title":"Additional file 3 of Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.14634182","title":"Additional file 3 of Interactions among mTORC, AMPK and SIRT: a computational model for cell energy balance and metabolism","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T09:31:10.799247Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}