{"doi":"10.1016/j.celrep.2016.08.069","title":"Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination","abstract":null,"journal":"Cell Reports","year":2016,"id":668097,"datarank":0.6798899239729885,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6798899239729885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1744625,"name":"Hélène Lenden Hasse","orcid":null,"position":1,"is_corresponding":false},{"id":1744626,"name":"Andrew N. Blackford","orcid":null,"position":2,"is_corresponding":false},{"id":41989,"name":"Gabriel Balmus","orcid":"0000-0003-2872-4468","position":3,"is_corresponding":false},{"id":1744627,"name":"Joy J. Bianchi","orcid":null,"position":4,"is_corresponding":false},{"id":725691,"name":"Wei Yu","orcid":"0000-0002-1777-5254","position":5,"is_corresponding":false},{"id":1744628,"name":"Léa Bacoccina","orcid":null,"position":6,"is_corresponding":false},{"id":845703,"name":"Angélique Jarade","orcid":"0000-0003-3695-3084","position":7,"is_corresponding":false},{"id":1744629,"name":"Christophe Clouin","orcid":null,"position":8,"is_corresponding":false},{"id":1744630,"name":"Rohan Sivapalan","orcid":null,"position":9,"is_corresponding":false},{"id":1744631,"name":"Bernardo Reina-San-Martin","orcid":null,"position":10,"is_corresponding":false},{"id":1744632,"name":"Stephen P. Jackson","orcid":null,"position":11,"is_corresponding":false},{"id":1744633,"name":"Ludovic Deriano","orcid":null,"position":12,"is_corresponding":false},{"id":1744624,"name":"Chloé Lescale","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination","abstract":"Paralog of XRCC4 and XLF (PAXX) is a member of the XRCC4 superfamily and plays a role in nonhomologous end-joining (NHEJ), a DNA repair pathway critical for lymphocyte antigen receptor gene assembly. Here, we find that the functions of PAXX and XLF in V(D)J recombination are masked by redundant joining activities. Thus, combined PAXX and XLF deficiency leads to an inability to join RAG-cleaved DNA ends. Additionally, we demonstrate that PAXX function in V(D)J recombination depends on its interaction with Ku. Importantly, we show that, unlike XLF, the role of PAXX during the repair of DNA breaks does not overlap with ATM and the RAG complex. Our findings illuminate the role of PAXX in V(D)J recombination and support a model in which PAXX and XLF function during NHEJ repair of DNA breaks, whereas XLF, the RAG complex, and the ATM-dependent DNA damage response promote end joining by stabilizing DNA ends.","is_dataset_classified":null,"base_score":4.532599493153256,"endowment":4.532599493153256,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27601299","pmcid":"PMC5033762","openalex_id":"https://openalex.org/W2511852522","authors":[],"funders":[{"funder_name":"Wellcome Trust","grant_id":"WT092096","title":null},{"funder_name":"European Research Council","grant_id":"310917","title":"Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers"},{"funder_name":"Cancer Research UK","grant_id":"C6/A18796","title":null},{"funder_name":"Cancer Research UK","grant_id":"C6946/A14492","title":null},{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"1511382","title":null},{"funder_name":"Cancer Research UK","grant_id":"18796","title":null},{"funder_name":"Wellcome Trust","grant_id":"092096","title":"Core support for the Wellcome Trust Cancer Research UK Gurdon Institute."},{"funder_name":"Institut Pasteur","grant_id":"","title":null}],"total_grants":8,"fwci":5.7735,"citation_percentile":0.96655316,"influential_citations":0,"citation_trend":[{"year":2016,"count":3},{"year":2017,"count":13},{"year":2018,"count":8},{"year":2019,"count":12},{"year":2020,"count":13},{"year":2021,"count":8},{"year":2022,"count":12},{"year":2023,"count":7},{"year":2024,"count":4},{"year":2025,"count":9},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2211124716311652/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124716311652/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124716311652?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124716311652?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2016.08.069","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27601299","host_type":"repository"},{"url":"https://www.repository.cam.ac.uk/handle/1810/260935","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5033762","host_type":"repository"},{"url":"https://pasteur.hal.science/pasteur-01369781","host_type":"repository"},{"url":"https://doaj.org/article/506134640cca44fdb752c066f4b3376f","host_type":"repository"},{"url":"https://doi.org/10.17863/cam.6109","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5033762","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.17863/cam.6109","host_type":""},{"url":"http://dx.doi.org/10.1016/j.celrep.2016.08.069","host_type":""},{"url":"https://dx.doi.org/10.1016/j.celrep.2016.08.069","host_type":""},{"url":"https://ora.ox.ac.uk/objects/uuid:6e56c61a-3bc6-4237-b2c3-83bda2925f2b","host_type":""},{"url":"https://pasteur.hal.science/pasteur-01369781v1/document","host_type":""},{"url":"https://pasteur.hal.science/pasteur-01369781v1","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.celrep.2016.08.069","host_type":""}],"fields_of_study":["DNA Repair Mechanisms","Immune Cell Function and Interaction","PARP inhibition in cancer therapy","0301 basic medicine","03 medical and health sciences","0303 health sciences","Animals","Ataxia Telangiectasia Mutated Proteins","B-Lymphocytes","CRISPR-Cas Systems","DNA Damage","DNA Repair","DNA Repair Enzymes","DNA-Binding Proteins","Gene Deletion","Gene Editing","Gene Rearrangement, B-Lymphocyte","Immunoglobulins","Ku Autoantigen","Models, Biological","Oncogene Proteins v-abl","Sequence Homology, Amino Acid","V(D)J Recombination"],"mesh_terms":["Ku Autoantigen","Gene Editing","Animals","B-Lymphocytes","DNA Damage","DNA Repair","DNA-Binding Proteins","Immunoglobulins","Models, Biological","Gene Rearrangement, B-Lymphocyte","Oncogene Proteins v-abl","Gene Deletion","Sequence Homology, Amino Acid","DNA Repair Enzymes","V(D)J Recombination","Ataxia Telangiectasia Mutated Proteins","CRISPR-Cas Systems"],"keywords":["V(D)J recombination","Non-homologous end joining","DNA repair protein XRCC4","DNA repair","DNA","Biology","Recombination","RAG2","Genetics","DNA-PKcs","Gene","Cell biology","DNA mismatch repair","Nhej","Xrcc4","Xlf","Paxx","Ataxia Telangiectasia Mutated Proteins/metabolism","DNA Repair Enzymes/metabolism","QH301-705.5","Sequence Homology","Immunoglobulins","Ataxia Telangiectasia Mutated Proteins","[SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology","Models, Biological","Article","[SDV.CAN] Life Sciences [q-bio]/Cancer","Models","Animals","B-Lymphocytes/metabolism","Biology (General)","Gene Rearrangement, B-Lymphocyte","Oncogene Proteins v-abl","Ku Autoantigen","Gene Rearrangement","Gene Editing","B-Lymphocytes","Sequence Homology, Amino Acid","Oncogene Proteins v-abl/metabolism","B-Lymphocyte","CRISPR-Cas Systems/genetics","V(D)J Recombination/genetics","Biological","Immunoglobulins/genetics","DNA-Binding Proteins","Amino Acid","DNA Repair Enzymes","Ku Autoantigen/metabolism","[SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology","CRISPR-Cas Systems","Gene Deletion","DNA-Binding Proteins/chemistry","DNA Damage"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T20:06:27.000088Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}