{"doi":"10.1016/j.celrep.2016.05.088","title":"RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression","abstract":"Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic. The transcriptional mechanisms controlling the pathogenicity of Th17 cells and IL-23R expression are unknown. Here, we demonstrate that the canonical Notch signaling mediator RBPJ is a key driver of IL-23R expression. In the absence of RBPJ, Th17 cells fail to upregulate IL-23R, lack stability, and do not induce autoimmune tissue inflammation in vivo, whereas overexpression of IL-23R rescues this defect and promotes pathogenicity of RBPJ-deficient Th17 cells. RBPJ binds and trans-activates the Il23r promoter and induces IL-23R expression and represses anti-inflammatory IL-10 production in Th17 cells. We thus find that Notch signaling influences the development of pathogenic and non-pathogenic Th17 cells by reciprocally regulating IL-23R and IL-10 expression.","journal":"Cell Reports","year":2016,"id":4717,"datarank":3.590761204494367,"base_score":4.727387818712341,"endowment":4.727387818712341,"self_citation_contribution":0.7091081728068512,"citation_network_contribution":2.8816530316875157,"self_endowment_contribution":0.7091081728068512,"citer_contribution":2.8816530316875157,"corpus_percentile":null,"corpus_rank":null,"citation_count":112,"citer_count":98,"citers_with_citation_signal":89,"citers_with_endowment":89,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2016-07-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":7853,"name":"Chuan Wu","orcid":"0000-0003-2288-353X","position":1,"is_corresponding":false},{"id":6927,"name":"Chao Wang","orcid":"0000-0003-3084-6093","position":2,"is_corresponding":false},{"id":15696,"name":"Le Cong","orcid":"0000-0003-4725-8714","position":3,"is_corresponding":false},{"id":7858,"name":"Mathias Pawlak","orcid":"0000-0002-4533-398X","position":4,"is_corresponding":false},{"id":7854,"name":"Youjin Lee","orcid":"0000-0002-7696-9446","position":5,"is_corresponding":false},{"id":31669,"name":"Wassim Elyaman","orcid":"0000-0001-7238-374X","position":6,"is_corresponding":false},{"id":7856,"name":"Sheng Xiao","orcid":"0000-0001-6252-8204","position":7,"is_corresponding":false},{"id":29633,"name":"Prisca Liberali","orcid":"0000-0003-0695-6081","position":8,"is_corresponding":false},{"id":6940,"name":"Vijay K. Kuchroo","orcid":"0000-0001-7177-2110","position":9,"is_corresponding":false},{"id":7869,"name":"Gerd Meyer zu Hörste","orcid":"0000-0002-4341-4719","position":10,"is_corresponding":false}],"reference_count":47,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}