{"doi":"10.1016/j.celrep.2014.12.032","title":"Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation","abstract":"Master regulators of the epithelial-mesenchymal transition such as Twist1 and Snail1 have been implicated in invasiveness and the generation of cancer stem cells, but their persistent activity inhibits stem-cell-like properties and the outgrowth of disseminated cancer cells into macroscopic metastases. Here, we show that Twist1 activation primes a subset of mammary epithelial cells for stem-cell-like properties, which only emerge and stably persist following Twist1 deactivation. Consequently, when cells undergo a mesenchymal-epithelial transition (MET), they do not return to their original epithelial cell state, evidenced by acquisition of invasive growth behavior and a distinct gene expression profile. These data provide an explanation for how transient Twist1 activation may promote all steps of the metastatic cascade; i.e., invasion, dissemination, and metastatic outgrowth at distant sites.","journal":"Cell Reports","year":2015,"id":9675,"datarank":0.7622106547476696,"base_score":5.081404364984463,"endowment":5.081404364984463,"self_citation_contribution":0.7622106547476696,"citation_network_contribution":0.0,"self_endowment_contribution":0.7622106547476696,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":160,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0473,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2015-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":80548,"name":"Elena Panzilius","orcid":null,"position":1,"is_corresponding":false},{"id":37452,"name":"Harald S. Bartsch","orcid":null,"position":2,"is_corresponding":false},{"id":556,"name":"Martin Irmler","orcid":"0000-0003-3169-479X","position":3,"is_corresponding":false},{"id":564,"name":"Johannes Beckers","orcid":"0000-0001-7874-3822","position":4,"is_corresponding":false},{"id":80549,"name":"Vijayalakshmi Kari","orcid":null,"position":5,"is_corresponding":false},{"id":37447,"name":"Jelena R. Linnemann","orcid":null,"position":6,"is_corresponding":false},{"id":80550,"name":"Diana Dragoi","orcid":null,"position":7,"is_corresponding":false},{"id":37451,"name":"Benjamin Hirschi","orcid":"0000-0002-1046-8307","position":8,"is_corresponding":false},{"id":37450,"name":"Uwe J. Kloos","orcid":null,"position":9,"is_corresponding":false},{"id":5613,"name":"Steffen Sass","orcid":"0000-0001-8939-1084","position":10,"is_corresponding":false},{"id":80551,"name":"Steffen Kahlert","orcid":null,"position":12,"is_corresponding":false},{"id":80552,"name":"Steven A. Johnsen","orcid":"0000-0003-1198-5805","position":13,"is_corresponding":false},{"id":37454,"name":"Karl Sotlar","orcid":"0000-0002-0116-3675","position":14,"is_corresponding":false},{"id":37455,"name":"Christina H. Scheel","orcid":null,"position":15,"is_corresponding":false},{"id":80553,"name":"Johanna Magdalena Schmidt","orcid":null,"position":16,"is_corresponding":false},{"id":37456,"name":"Harald Bartsch","orcid":null,"position":17,"is_corresponding":false},{"id":80554,"name":"Diana Drăgoi","orcid":null,"position":18,"is_corresponding":false},{"id":42,"name":"Fabian Joachim Theis","orcid":"0000-0002-2419-1943","position":19,"is_corresponding":false},{"id":37458,"name":"Christina Scheel","orcid":"0000-0003-0566-4650","position":20,"is_corresponding":false},{"id":80547,"name":"Johanna M. Schmidt","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}