{"doi":"10.1016/j.cellsig.2021.109929","title":"Lipid rafts as platforms for sphingosine 1-phosphate metabolism and signalling","abstract":null,"journal":"Cellular Signalling","year":2021,"id":627245,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1589414,"name":"Simona Prioni","orcid":null,"position":1,"is_corresponding":false},{"id":163914,"name":"Laura Mauri","orcid":null,"position":2,"is_corresponding":false},{"id":1589413,"name":"Alessandro Prinetti","orcid":null,"position":3,"is_corresponding":false},{"id":1623033,"name":"Sara Grassi","orcid":null,"position":4,"is_corresponding":false},{"id":1623032,"name":"Chiara D'Aprile","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lipid rafts as platforms for sphingosine 1-phosphate metabolism and signalling","abstract":"Spontaneous segregation of cholesterol and sphingolipids as a liquid-ordered phase leads to their clustering in selected membrane areas, the lipid rafts. These specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol and selected proteins involved in signal transduction, organize and determine the function of multiprotein complexes involved in several aspects of signal transduction, thus regulating cell homeostasis. Sphingosine 1-phosphate, an important biologically active mediator, is involved in several signal transduction processes regulating a plethora of cell functions and, not only several of its downstream effectors tend to localize in lipid rafts, some of the enzymes involved in its pathway, of receptors involved in its signalling and its transporters have been often found in these membrane microdomains. Considering this, in this review we address what is currently known regarding the relationship between sphingosine 1-phosphate metabolism and signalling and plasma membrane lipid rafts.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33493577","pmcid":null,"openalex_id":"https://openalex.org/W3122908521","authors":[],"funders":[],"total_grants":0,"fwci":1.4804,"citation_percentile":0.81852906,"influential_citations":0,"citation_trend":[{"year":2021,"count":4},{"year":2022,"count":7},{"year":2023,"count":3},{"year":2024,"count":6},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0898656821000176?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0898656821000176?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cellsig.2021.109929","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33493577","host_type":"repository"},{"url":"https://hdl.handle.net/10281/588681","host_type":"repository"}],"fields_of_study":["Sphingolipid Metabolism and Signaling","Lipid Membrane Structure and Behavior","Cellular transport and secretion"],"mesh_terms":["Sphingosine-1-Phosphate Receptors","Sphingosine Kinase","Aldehyde-Lyases","Humans","Lysophospholipids","Membrane Proteins","Phosphoric Monoester Hydrolases","Sphingosine","Signal Transduction","Phosphotransferases (Alcohol Group Acceptor)","Receptor Cross-Talk","Membrane Microdomains","Caveolin 1"],"keywords":["Lipid raft","Sphingolipid","Cell biology","Signal transduction","Sphingomyelin","Sphingosine","Lipid signaling","Biology","Sphingosine-1-phosphate","Sphingosine kinase","Ceramide","Cell signaling","Lipid microdomain","Cell membrane","Biochemistry","Cell","Receptor","Membrane","lipid rafts","sphingosine 1-phosphate","S1p Lyase","Sphingosine 1-Phosphate Receptors","S1p Phosphatases"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T16:48:48.567989Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}