{"doi":"10.1016/j.cellimm.2020.104112","title":"Combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model","abstract":null,"journal":"Cellular Immunology","year":2020,"id":685952,"datarank":0.5983476069846413,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"self_citation_contribution":0.5983476069846413,"citation_network_contribution":0.0,"self_endowment_contribution":0.5983476069846413,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792147,"name":"Qingtian Liu","orcid":null,"position":1,"is_corresponding":false},{"id":1792148,"name":"Tong Zuo","orcid":null,"position":2,"is_corresponding":false},{"id":1792149,"name":"Guoyan Wei","orcid":null,"position":3,"is_corresponding":false},{"id":1792150,"name":"Shunchang Jiao","orcid":null,"position":4,"is_corresponding":false},{"id":1792146,"name":"Yujie Song","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model","abstract":"Glioblastoma is one of the deadliest cancers. Chimeric antigen receptor (CAR)-T cell therapy against solid tumors has been far from satisfactory largely due to the immunosuppressive tumor microenvironment, such as PD-1 mediated T cell exhaustion. In the present study, we investigated the combined antitumor effects of anti-EGFR variant III CAR-T cell therapy and PD-1 checkpoint blockade on glioblastoma in mouse model. The results demonstrated that CAR-T cells with PD-1 blockade exhibit higher killing efficiency in vitro. Additionally, CAR-T cells with PD-1 blockade showed more effective and persistent therapeutic effects on glioblastoma and led to significantly increased number of tumor infiltrating lymphocytes (TILs) in the mouse model. In conclusion, PD-1 checkpoint blockade significantly enhanced the antitumor activity of anti-human EGFRvIII CAR-T cells by overcoming TILs exhaustion. The outcomes of the present study provide a novel strategy for improving the potency of CAR-T cell therapies in solid tumors.","is_dataset_classified":null,"base_score":3.9889840465642745,"endowment":3.9889840465642745,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32305131","pmcid":null,"openalex_id":"https://openalex.org/W3015923357","authors":[],"funders":[],"total_grants":0,"fwci":2.052,"citation_percentile":0.89259752,"influential_citations":0,"citation_trend":[{"year":2020,"count":3},{"year":2021,"count":6},{"year":2022,"count":12},{"year":2023,"count":6},{"year":2024,"count":15},{"year":2025,"count":7},{"year":2026,"count":4}],"oa_status":"closed","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0008874920300228?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0008874920300228?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cellimm.2020.104112","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32305131","host_type":"repository"}],"fields_of_study":["CAR-T cell therapy research","Cancer Immunotherapy and Biomarkers","Immunotherapy and Immune Responses","Animals","Cell Line, Tumor","Disease Models, Animal","ErbB Receptors","Female","Glioblastoma","Humans","Immunotherapy, Adoptive","Lymphocytes, Tumor-Infiltrating","Mice","Mice, Nude","Programmed Cell Death 1 Receptor","Receptors, Chimeric Antigen","T-Lymphocytes","Tumor Microenvironment","Xenograft Model Antitumor Assays"],"mesh_terms":["Receptors, Chimeric Antigen","Animals","Disease Models, Animal","Female","Glioblastoma","Humans","Mice, Nude","T-Lymphocytes","Immunotherapy, Adoptive","Lymphocytes, Tumor-Infiltrating","Xenograft Model Antitumor Assays","Cell Line, Tumor","Mice","Tumor Microenvironment","Programmed Cell Death 1 Receptor","ErbB Receptors"],"keywords":["Blockade","Chimeric antigen receptor","Cancer research","Glioblastoma","Tumor microenvironment","Immune checkpoint","T cell","CAR T-cell therapy","Cytotoxic T cell","Potency","Neoplasm","In vitro","Biology","Immunology","Medicine","Receptor","Immune system","Tumor cells","Internal medicine","Pathology","Programmed death-1","Programmed Death-ligand 1","Egfr Variant Iii"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T18:09:07.719182Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}