{"doi":"10.1016/j.cell.2025.12.046","title":"EBV infection and HLA-DR15 jointly drive multiple sclerosis by myelin peptide presentation","abstract":null,"journal":"Cell","year":2026,"id":624872,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":994545,"name":"Yuhan Qiu","orcid":"0000-0003-3770-7977","position":1,"is_corresponding":false},{"id":1615483,"name":"Zoe Marti","orcid":null,"position":2,"is_corresponding":false},{"id":1216036,"name":"Fengqi Li","orcid":"0000-0002-1670-6062","position":3,"is_corresponding":false},{"id":1615484,"name":"Marcel Wacker","orcid":null,"position":4,"is_corresponding":false},{"id":1615485,"name":"Pietro Oldrati","orcid":null,"position":5,"is_corresponding":false},{"id":1615486,"name":"Lena Mühlenbruch","orcid":null,"position":6,"is_corresponding":false},{"id":1615487,"name":"Linlin Jin","orcid":null,"position":7,"is_corresponding":false},{"id":499288,"name":"Hongxia Zhang","orcid":"0000-0003-1594-6707","position":8,"is_corresponding":false},{"id":133781,"name":"Wen Xu","orcid":null,"position":9,"is_corresponding":false},{"id":1005188,"name":"Tingting Li","orcid":"0000-0001-7331-9619","position":10,"is_corresponding":false},{"id":658799,"name":"Bernd Roschitzki","orcid":"0000-0001-5756-9773","position":11,"is_corresponding":false},{"id":1615488,"name":"Wolfgang Faigle","orcid":null,"position":12,"is_corresponding":false},{"id":1538284,"name":"Yingjun Liu","orcid":"0000-0003-1543-1965","position":13,"is_corresponding":false},{"id":1615489,"name":"Julie T. 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Among several mechanisms of how EBV may contribute are transcriptome alterations, including changes of antigen processing and preferential presentation of both viral and self-antigens. Here, we report that EBV reprograms the transcriptome and immunopeptidome presented on the MS-associated human leukocyte antigen (HLA)-DR15 molecules of infected B cells. Identical myelin basic protein (MBP) peptides were found to be presented on both EBV-infected B cells and MS brain tissue but not primary B cells and thymic tissue. Peripheral memory and cerebrospinal fluid (CSF)-derived CD4 + T cells of HLA-DR15 + MS patients responded to MBP peptides, MBP (78–90) and/or MBP (83–90) , and T cell clones raised with these peptides recognized all MBP peptides ending at amino acid MBP 90 in MS brain tissue. Our study provides a new mechanistic link for how the environmental and genetic risk factors, EBV infection and HLA-DR15 haplotype, may contribute jointly to MS.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41534530","pmcid":null,"openalex_id":"https://openalex.org/W7123438916","authors":[],"funders":[{"funder_name":"Carl-Zeiss-Stiftung","grant_id":"P2024-02-012","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"WK3520000016","title":null},{"funder_name":"European Research Council","grant_id":"ERC-2013-ADG 340733","title":null},{"funder_name":"HORIZON EUROPE Framework Programme","grant_id":"101137235","title":"The role of an Epstein-Barr virus infection in the pathogenesis of multiple sclerosis"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"WA4608/1-2","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"EXC2180-390900677","title":null},{"funder_name":"Deutsche Krebshilfe","grant_id":"70114948","title":null},{"funder_name":"Deutsche Krebshilfe","grant_id":"BW1_4064/03","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFC2304102","title":null},{"funder_name":"Chinese Academy of Sciences","grant_id":"XDB0940303","title":null},{"funder_name":"Chinese Academy of Sciences","grant_id":"XDB0490301","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"92469102","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82271827","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82471757","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32470954","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32300747","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"European Commission","grant_id":"340733","title":"Functional Role of the HLA-DR15 Haplotype in Multiple Sclerosis"},{"funder_name":"European Commission","grant_id":"","title":null},{"funder_name":"Deutschen Konsortium für Translationale Krebsforschung","grant_id":"","title":null},{"funder_name":"University of Zurich","grant_id":"","title":null}],"total_grants":21,"fwci":205.9199,"citation_percentile":0.99995641,"influential_citations":0,"citation_trend":[{"year":2026,"count":27}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.cell.2025.12.046","host_type":"journal"},{"url":"https://doi.org/10.1016/j.cell.2025.12.046","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867425014953?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867425014953?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41534530","host_type":"repository"},{"url":"http://hdl.handle.net/20.500.11850/793314","host_type":"repository"},{"url":"https://dx.doi.org/10.5167/uzh-290993","host_type":""},{"url":"https://dx.doi.org/10.3929/ethz-c-000793314","host_type":""},{"url":"https://hdl.handle.net/11562/1186787","host_type":""},{"url":"https://doi.org/https://doi.org/10.1016/j.cell.2025.12.046","host_type":""},{"url":"http://dx.doi.org/10.1016/J.CELL.2025.12.046","host_type":""},{"url":"http://dx.doi.org/10.1016/j.cell.2025.12.046","host_type":""}],"fields_of_study":["Multiple Sclerosis Research Studies","vaccines and immunoinformatics approaches","Immunotherapy and Immune Responses","0301 basic medicine","03 medical and health sciences","Humans","Multiple Sclerosis","HLA-DR Serological Subtypes","Herpesvirus 4, Human","Epstein-Barr Virus Infections","Myelin Basic Protein","B-Lymphocytes","Brain","CD4-Positive T-Lymphocytes","Female","Antigen Presentation","Peptides","Adult","Male","Myelin Sheath","Middle Aged"],"mesh_terms":["Adult","B-Lymphocytes","Brain","Myelin Basic Protein","Herpesvirus 4, Human","Female","Humans","Male","Middle Aged","Multiple Sclerosis","Myelin Sheath","Peptides","CD4-Positive T-Lymphocytes","Antigen Presentation","Epstein-Barr Virus Infections","HLA-DR Serological Subtypes"],"keywords":["Multiple sclerosis","Transcriptome","Antigen presentation","Myelin","Antigen","Antigen processing","Myelin basic protein","Peptide","Brain tissue","Epstein-Barr virus","B cells","Immunopeptidome","Thymic Tissue","Autoreactive Cd4(+) T Cells","Myelin Basic Protein Peptide","Male","CD4-Positive T-Lymphocytes","Adult","Epstein-Barr Virus Infections","Herpesvirus 4, Human","Humans","610 Medicine & health","HLA-DR Serological Subtypes","B-Lymphocytes","Brain","Middle Aged","570 Life sciences; 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