{"doi":"10.1016/j.cell.2025.11.035","title":"Next steps in regulatory T cells: Biology and clinical application","abstract":null,"journal":"Cell","year":2026,"id":622401,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":964378,"name":"Peiying Li","orcid":"0000-0002-5721-9914","position":1,"is_corresponding":false},{"id":556373,"name":"Bin Li","orcid":"0000-0003-2945-4092","position":2,"is_corresponding":false},{"id":292171,"name":"Tim Sparwasser","orcid":"0000-0001-5645-902X","position":3,"is_corresponding":false},{"id":227123,"name":"Junying Yuan","orcid":"0000-0003-2405-6036","position":4,"is_corresponding":false},{"id":1608120,"name":"Chengyu Zou","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Next steps in regulatory T cells: Biology and clinical application","abstract":"Recent advances in regulatory T cell (Treg) biology and clinical application of Treg-based treatments show promise as a new generation of transforming therapeutics for immune-related disorders, positioning Tregs as a \"living drug\" to rebuild immune tolerance and repair damaged tissues simultaneously. This perspective summarizes the key knowledge on Treg biology and highlights the recent important discoveries in the development of clinical applications based on Treg biology, from low-dose interleukin-2 therapy showing promising results in trials for ALS and adoptive Treg transfer demonstrating efficacy in preventing GVHD to early pilot studies of CAR Tregs. Drawing on these advances, we provide perspectives on key research priorities and translational challenges and set forth a roadmap that integrates basic and clinical insights into developing next-generation therapies focusing on precision tolerance strategies.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41512846","pmcid":null,"openalex_id":"https://openalex.org/W7119530283","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"U22A20295","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82188101","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"2025","title":null},{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"22JC1410400","title":null}],"total_grants":4,"fwci":56.3243,"citation_percentile":0.99951679,"influential_citations":0,"citation_trend":[{"year":2026,"count":14}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0092867425013704?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867425013704?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cell.2025.11.035","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41512846","host_type":"repository"}],"fields_of_study":["T-cell and B-cell Immunology","vaccines and immunoinformatics approaches","CAR-T cell therapy research","T-Lymphocytes, Regulatory","Humans","Animals","Interleukin-2","Immune Tolerance","Graft vs Host Disease","Amyotrophic Lateral Sclerosis","Forkhead Transcription Factors"],"mesh_terms":["Amyotrophic Lateral Sclerosis","Animals","Graft vs Host Disease","Humans","Immune Tolerance","Interleukin-2","T-Lymphocytes, Regulatory","Forkhead Transcription Factors"],"keywords":["Translational research","Adoptive cell transfer","Key (lock)","Clinical trial","Systems biology","Set (abstract data type)","Immune system","Cell therapy","GVHD","AD","ALS","autoimmune disease","Treg","FOXP3"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T19:28:31.872787Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}