{"doi":"10.1016/j.cell.2025.10.008","title":"A single-nucleus transcriptomic atlas of the adult Aedes aegypti mosquito","abstract":"The female Aedes aegypti mosquito's remarkable ability to hunt humans and transmit pathogens relies on her unique biology. Here, we present the Aedes aegypti Mosquito Cell Atlas, a comprehensive single-nucleus RNA sequencing dataset of more than 367,000 nuclei from 19 dissected tissues of adult female and male Aedes aegypti, providing cellular-level resolution of mosquito biology. We identify novel cell types and expand our understanding of sensory neuron organization of chemoreceptors across all sensory tissues. Our analysis uncovers male-specific cells and sexually dimorphic gene expression in the antenna and brain. In female mosquitoes, we find that glial cells, rather than neurons, undergo the most extensive transcriptional changes in the brain following blood feeding. Our findings provide insights into the cellular basis of mosquito behavior and sexual dimorphism. The Aedes aegypti Mosquito Cell Atlas resource enables systematic investigation of cell-type-specific expression across all mosquito tissues.","journal":"Cell","year":2025,"id":510523,"datarank":0.48362065225877415,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.026942286600260656,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.026942286600260656,"corpus_percentile":60.51674789200897,"corpus_rank":5105,"citation_count":20,"citer_count":17,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.925,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":62.5,"fair_percentile":81.0149801284011,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1367623,"name":"Alexandra E. 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Tsitohay","orcid":"0000-0002-8716-9444","position":11,"is_corresponding":false},{"id":1367624,"name":"Madison M. Walker","orcid":null,"position":12,"is_corresponding":false},{"id":343014,"name":"Ben R. Hopkins","orcid":"0000-0002-9760-6185","position":13,"is_corresponding":false},{"id":1367625,"name":"Joshua X.D. Ang","orcid":null,"position":14,"is_corresponding":false},{"id":242214,"name":"Igor Antoshechkin","orcid":"0000-0002-9934-3040","position":15,"is_corresponding":false},{"id":531851,"name":"Yu Cai","orcid":"0000-0001-7787-8610","position":16,"is_corresponding":false},{"id":1237520,"name":"Fangying Chen","orcid":"0000-0003-0840-5726","position":17,"is_corresponding":false},{"id":1367626,"name":"Yen-Chung Chen","orcid":null,"position":18,"is_corresponding":false},{"id":1367627,"name":"Julien Devilliers","orcid":null,"position":19,"is_corresponding":false},{"id":1367628,"name":"Linhan Dong","orcid":"0009-0002-6668-2326","position":20,"is_corresponding":false},{"id":621605,"name":"Roberto Feuda","orcid":"0000-0003-0857-1732","position":21,"is_corresponding":false},{"id":380788,"name":"Paolo Gabrieli","orcid":"0000-0002-4996-2468","position":22,"is_corresponding":false},{"id":52148,"name":"Artyom Kopp","orcid":"0000-0001-5224-0741","position":23,"is_corresponding":false},{"id":379181,"name":"Hyeogsun Kwon","orcid":"0000-0002-4141-4061","position":24,"is_corresponding":false},{"id":282257,"name":"Hsing-Han Li","orcid":"0000-0003-4984-7942","position":25,"is_corresponding":false},{"id":551913,"name":"Tzu‐Chiao Lu","orcid":"0000-0001-9942-2307","position":26,"is_corresponding":false},{"id":1366916,"name":"Thalita Lucio","orcid":"0009-0001-7817-548X","position":27,"is_corresponding":false},{"id":468115,"name":"João T. Marques","orcid":"0000-0002-3457-3320","position":28,"is_corresponding":false},{"id":325895,"name":"Marcus F. Oliveira","orcid":"0000-0002-9890-8425","position":29,"is_corresponding":false},{"id":895354,"name":"Roenick Proveti Olmo","orcid":"0000-0002-3849-8591","position":30,"is_corresponding":false},{"id":262196,"name":"Umberto Palatini","orcid":"0000-0002-2435-2655","position":31,"is_corresponding":false},{"id":1367629,"name":"Zeaan M. Pithawala","orcid":null,"position":32,"is_corresponding":false},{"id":895167,"name":"Julien Pompon","orcid":"0000-0003-1110-9039","position":33,"is_corresponding":false},{"id":1367630,"name":"Yan Reis","orcid":null,"position":34,"is_corresponding":false},{"id":1367631,"name":"João Marcos Ranyere da Silva Rodrigues","orcid":null,"position":35,"is_corresponding":false},{"id":379184,"name":"Ryan C. Smith","orcid":"0000-0003-0245-2265","position":36,"is_corresponding":false},{"id":24474,"name":"Maximilian Haeussler","orcid":"0000-0001-8721-8253","position":37,"is_corresponding":false},{"id":262214,"name":"Omar S. Akbari","orcid":"0000-0002-6853-9884","position":38,"is_corresponding":false},{"id":376579,"name":"Laura B. Duvall","orcid":"0000-0002-1821-6809","position":39,"is_corresponding":false},{"id":1367632,"name":"Helen White-Cooper","orcid":null,"position":40,"is_corresponding":false},{"id":395736,"name":"Trevor R. Sorrells","orcid":"0000-0002-3527-8622","position":41,"is_corresponding":false},{"id":240161,"name":"Roshan Sharma","orcid":"0000-0001-9886-009X","position":42,"is_corresponding":false},{"id":242235,"name":"Hongjie Li","orcid":"0000-0002-7332-7122","position":43,"is_corresponding":false},{"id":267007,"name":"Leslie B. Vosshall","orcid":"0000-0002-6060-8099","position":44,"is_corresponding":false},{"id":990149,"name":"Nadav Shai","orcid":"0000-0002-2812-3884","position":45,"is_corresponding":false},{"id":551912,"name":"Olivia V. Goldman","orcid":"0000-0001-9339-347X","position":0,"is_corresponding":true}],"reference_count":199,"raw_metadata":null,"created_at":"2026-07-19T02:47:36.538276Z","pmid":"41172998","pmcid":"PMC12767863","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":83.3333,"fair_a":62.5,"fair_i":20.0,"fair_r":33.3333,"fair_zscore":1.1103,"fair_rationale":{"fair_score":62.5,"has_llm":true,"taxonomy_version":"fair_taxonomy_v5","dimensions":{"F":{"name":"Findable","score":83.33,"criteria":[{"key":"f_dataset_pid","label":"Persistent identifier for the data","kind":"llm","weight":2.0,"fraction":1.0,"verdict":"yes","evidence":"Additional processed data, plots, analysis and custom scripts are available at Zenodo Supplemental Data ( https://doi.org/10.5281/zenodo.14890012 ).","grounded":true,"rationale":"The paper provides a DOI (10.5281/zenodo.14890012) for the additional processed data, which is a persistent identifier scheme. 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An author-gated dataset dies with the author's email address, and 'on reasonable request' has been shown repeatedly not to yield data.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"The study involves mosquito data, not human or sensitive data, and no gatekeeper is named; the data are openly accessible without restriction.","gain":0.0,"priority":"useful","scored":false},{"key":"a_timeline_retention","dimension":"A","label":"Availability timing & retention","action":"State when the data become available AND how long they will be retained — cite the repository's preservation policy. NIH DMS Element 4 asks for both; most papers give neither.","anchors":["yes","partial","no"],"verdict":"no","current":0.0,"evidence":null,"why":"No sentence states when the data become available or how long they persist. [majority verdict 'no' (3/5 passes agreed)]","gain":0.0,"priority":"useful","scored":false}],"suggestions":["Attach a standard, machine-readable open licence to the deposit — CC0 or CC BY, which is what Horizon Europe and most funders expect — and print the licence identifier in the paper. 'Free to use' is not a licence: it grants nothing a reuser's institution can rely on.","Release the data in an open, community-standard format (CSV/TSV, JSON, HDF5, NetCDF, FASTQ, VCF, NIfTI…) instead of — or alongside — any proprietary or instrument-native format, and name the format in the paper. A dataset that needs a €2,000 licence to open is not reusable. Prefer open proteomics formats such as mzML or mzIdentML.","Cite the dataset in the reference list like a publication — creator, year, title, repository, DOI/accession — and cite it in-text where it is used. Only a reference- list entry is machine-readable to Crossref/DataCite, and only a citation lets the data earn credit. Cite the proteomics repository accession (e.g. from PRIDE (PXD accession) or ProteomeXchange) in the reference list.","Version the deposit and cite the exact version analysed (a version-specific DOI, or an accession with its version suffix). A reader reproducing your work against 'the current release' is reproducing it against a different dataset.","State the funder AND the award number in the paper, and put them in the dataset's FundingReference metadata. A funder name alone cannot be linked back to the award, so the funding provenance of the data is lost the moment the paper is indexed."],"model":"deepseek/deepseek-v4-flash","agent_version":"fair_agent_v8","fulltext_source":"epmc_xml"},"fair_model":"deepseek/deepseek-v4-flash","fair_agent_version":"fair_agent_v8","fair_fulltext_source":"epmc_xml","fair_has_llm":true,"fair_computed_at":"2026-07-20T11:53:59.129072Z","clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}