{"doi":"10.1016/j.cell.2024.02.019","title":"The underappreciated diversity of bile acid modifications","abstract":"The repertoire of modifications to bile acids and related steroidal lipids by host and microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource of tandem mass spectrometry (MS/MS) spectra by filtering 1.2 billion publicly available MS/MS spectra for bile-acid-selective ion patterns. Thousands of modifications are distributed throughout animal and human bodies as well as microbial cultures. We employed this MS/MS library to identify polyamine bile amidates, prevalent in carnivores. They are present in humans, and their levels alter with a diet change from a Mediterranean to a typical American diet. This work highlights the existence of many more bile acid modifications than previously recognized and the value of leveraging public large-scale untargeted metabolomics data to discover metabolites. The availability of a modification-centric bile acid MS/MS library will inform future studies investigating bile acid roles in health and disease.","journal":"Cell","year":2024,"id":416252,"datarank":3.1705117701209145,"base_score":5.262690188904886,"endowment":5.262690188904886,"self_citation_contribution":0.7894035283357329,"citation_network_contribution":2.3811082417851814,"self_endowment_contribution":0.7894035283357329,"citer_contribution":2.3811082417851814,"corpus_percentile":93.02235630850159,"corpus_rank":903,"citation_count":192,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.6188,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":553982,"name":"Helena Mannochio-Russo","orcid":"0000-0002-4961-2353","position":1,"is_corresponding":false},{"id":1200467,"name":"Joshua V. Schweer","orcid":null,"position":2,"is_corresponding":false},{"id":1161288,"name":"Yasin El Abiead","orcid":"0000-0003-4392-7706","position":3,"is_corresponding":false},{"id":255007,"name":"Wout Bittremieux","orcid":"0000-0002-3105-1359","position":4,"is_corresponding":false},{"id":983399,"name":"Shipei Xing","orcid":"0000-0001-6227-6959","position":5,"is_corresponding":false},{"id":255044,"name":"Robin Schmid","orcid":"0000-0003-0922-3887","position":6,"is_corresponding":false},{"id":363451,"name":"Simone Zuffa","orcid":"0000-0001-7237-3402","position":7,"is_corresponding":false},{"id":1200468,"name":"Felipe Vasquez","orcid":null,"position":8,"is_corresponding":false},{"id":1200469,"name":"Valentina B. Muti","orcid":null,"position":9,"is_corresponding":false},{"id":983400,"name":"Jasmine Zemlin","orcid":"0000-0003-0713-9956","position":10,"is_corresponding":false},{"id":1199384,"name":"Omar E. Tovar-Herrera","orcid":"0000-0001-7627-644X","position":11,"is_corresponding":false},{"id":905218,"name":"Sarah Moraïs","orcid":"0000-0001-9026-2386","position":12,"is_corresponding":false},{"id":375974,"name":"Dhimant Desai","orcid":"0000-0001-9367-8600","position":13,"is_corresponding":false},{"id":240452,"name":"Shantu Amin","orcid":"0000-0003-2780-2567","position":14,"is_corresponding":false},{"id":239562,"name":"Imhoi Koo","orcid":"0000-0002-5816-0627","position":15,"is_corresponding":false},{"id":48954,"name":"Christoph W. Turck","orcid":"0000-0002-6585-8636","position":16,"is_corresponding":false},{"id":255027,"name":"Itzhak Mizrahi","orcid":"0000-0001-6636-8818","position":17,"is_corresponding":false},{"id":233815,"name":"Penny M. Kris‐Etherton","orcid":"0000-0001-6012-4900","position":18,"is_corresponding":false},{"id":477708,"name":"Kristina H. Petersen","orcid":"0000-0002-1944-6972","position":19,"is_corresponding":false},{"id":504760,"name":"Jennifer Fleming","orcid":"0000-0003-1009-0225","position":20,"is_corresponding":false},{"id":271656,"name":"Tao Huan","orcid":"0000-0001-6295-2435","position":21,"is_corresponding":false},{"id":239569,"name":"Andrew D. Patterson","orcid":"0000-0003-2073-0070","position":22,"is_corresponding":false},{"id":225261,"name":"Dionicio Siegel","orcid":"0000-0003-4674-9554","position":23,"is_corresponding":false},{"id":1085125,"name":"Lee R. Hagey","orcid":null,"position":24,"is_corresponding":false},{"id":3548,"name":"Mingxun Wang","orcid":"0000-0001-7647-6097","position":25,"is_corresponding":false},{"id":251370,"name":"Allegra T. Aron","orcid":"0000-0002-9596-021X","position":26,"is_corresponding":false},{"id":3553,"name":"Pieter C. Dorrestein","orcid":"0000-0002-3003-1030","position":27,"is_corresponding":false},{"id":1199348,"name":"Ipsita Mohanty","orcid":"0000-0001-5311-6443","position":0,"is_corresponding":true}],"reference_count":122,"raw_metadata":null,"created_at":"2026-07-19T01:56:20.964471Z","pmid":"38471500","pmcid":"PMC12248420","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}