{"doi":"10.1016/j.cell.2023.12.037","title":"Xist ribonucleoproteins promote female sex-biased autoimmunity","abstract":"Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) is expressed only in females to randomly inactivate one of the two X chromosomes to achieve gene dosage compensation. Here, we show that the Xist ribonucleoprotein (RNP) complex comprising numerous autoantigenic components is an important driver of sex-biased autoimmunity. Inducible transgenic expression of a non-silencing form of Xist in male mice introduced Xist RNP complexes and sufficed to produce autoantibodies. Male SJL/J mice expressing transgenic Xist developed more severe multi-organ pathology in a pristane-induced lupus model than wild-type males. Xist expression in males reprogrammed T and B cell populations and chromatin states to more resemble wild-type females. Human patients with autoimmune diseases displayed significant autoantibodies to multiple components of XIST RNP. Thus, a sex-specific lncRNA scaffolds ubiquitous RNP components to drive sex-biased immunity.","journal":"Cell","year":2024,"id":416213,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":216,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235903,"name":"Yanding Zhao","orcid":"0000-0002-6882-4888","position":1,"is_corresponding":false},{"id":262617,"name":"Julia A. Belk","orcid":"0000-0003-4724-6158","position":2,"is_corresponding":false},{"id":283146,"name":"Yang Zhao","orcid":"0000-0002-0856-2724","position":3,"is_corresponding":false},{"id":232222,"name":"Kerriann M. Casey","orcid":"0000-0003-4228-928X","position":4,"is_corresponding":false},{"id":805784,"name":"Derek C. Chen","orcid":"0000-0001-9652-4885","position":5,"is_corresponding":false},{"id":512005,"name":"Rui Li","orcid":"0000-0003-2318-9232","position":6,"is_corresponding":false},{"id":236071,"name":"Bingfei Yu","orcid":"0000-0001-5550-6701","position":7,"is_corresponding":false},{"id":398199,"name":"Suhas Srinivasan","orcid":"0000-0001-8309-9648","position":8,"is_corresponding":false},{"id":839589,"name":"Brian T. Abe","orcid":"0000-0002-1262-5556","position":9,"is_corresponding":false},{"id":554420,"name":"Katerina Kraft","orcid":"0000-0002-2011-6946","position":10,"is_corresponding":false},{"id":1200416,"name":"Ceke Hellström","orcid":null,"position":11,"is_corresponding":false},{"id":1199282,"name":"Ronald Sjöberg","orcid":"0000-0003-1363-5796","position":12,"is_corresponding":false},{"id":498105,"name":"Sarah E. Chang","orcid":"0009-0008-9986-1666","position":13,"is_corresponding":false},{"id":615590,"name":"Allan Feng","orcid":"0000-0003-0122-7947","position":14,"is_corresponding":false},{"id":399328,"name":"Daniel Goldman","orcid":"0000-0001-5003-3503","position":15,"is_corresponding":false},{"id":313830,"name":"Ami A. Shah","orcid":"0000-0002-1139-2009","position":16,"is_corresponding":false},{"id":278767,"name":"Michelle Petri","orcid":"0000-0003-1441-5373","position":17,"is_corresponding":false},{"id":1200417,"name":"Lorinda S. Chung","orcid":null,"position":18,"is_corresponding":false},{"id":738770,"name":"David Fiorentino","orcid":"0000-0001-7951-3674","position":19,"is_corresponding":false},{"id":44848,"name":"Emma Lundberg","orcid":"0000-0001-7034-0850","position":20,"is_corresponding":false},{"id":1199283,"name":"Anton Wutz","orcid":"0000-0002-4377-6330","position":21,"is_corresponding":false},{"id":22091,"name":"Paul J. Utz","orcid":"0000-0003-1181-1565","position":22,"is_corresponding":false},{"id":26,"name":"Howard Y. Chang","orcid":"0000-0002-9459-4393","position":23,"is_corresponding":false},{"id":283143,"name":"Diana R. Dou","orcid":"0000-0001-6269-9636","position":0,"is_corresponding":true}],"reference_count":108,"raw_metadata":null,"created_at":"2026-07-19T01:56:20.964471Z","pmid":"38306984","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}