{"doi":"10.1016/j.cell.2023.08.032","title":"A disordered region controls cBAF activity via condensation and partner recruitment","abstract":"Intrinsically disordered regions (IDRs) represent a large percentage of overall nuclear protein content. The prevailing dogma is that IDRs engage in non-specific interactions because they are poorly constrained by evolutionary selection. Here, we demonstrate that condensate formation and heterotypic interactions are distinct and separable features of an IDR within the ARID1A/B subunits of the mSWI/SNF chromatin remodeler, cBAF, and establish distinct \"sequence grammars\" underlying each contribution. Condensation is driven by uniformly distributed tyrosine residues, and partner interactions are mediated by non-random blocks rich in alanine, glycine, and glutamine residues. These features concentrate a specific cBAF protein-protein interaction network and are essential for chromatin localization and activity. Importantly, human disease-associated perturbations in ARID1B IDR sequence grammars disrupt cBAF function in cells. Together, these data identify IDR contributions to chromatin remodeling and explain how phase separation provides a mechanism through which both genomic localization and functional partner recruitment are achieved.","journal":"Cell","year":2023,"id":315484,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":157,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":108002,"name":"Amy R. Strom","orcid":"0000-0002-1674-3242","position":1,"is_corresponding":false},{"id":136624,"name":"Joao A. Paulo","orcid":"0000-0002-4291-413X","position":2,"is_corresponding":false},{"id":573661,"name":"Clayton K. Collings","orcid":"0000-0002-3471-2132","position":3,"is_corresponding":false},{"id":257881,"name":"Kiersten M. Ruff","orcid":"0000-0003-3240-1856","position":4,"is_corresponding":false},{"id":418457,"name":"Min Kyung Shinn","orcid":"0000-0003-2713-5602","position":5,"is_corresponding":false},{"id":248539,"name":"Akshay Sankar","orcid":null,"position":6,"is_corresponding":false},{"id":1007929,"name":"Kasey S. Cervantes","orcid":null,"position":7,"is_corresponding":false},{"id":1017531,"name":"Tobias Wauer","orcid":null,"position":8,"is_corresponding":false},{"id":520957,"name":"Jessica D. St. Laurent","orcid":"0000-0002-9422-8713","position":9,"is_corresponding":false},{"id":1016731,"name":"Hui Xu","orcid":"0000-0002-3421-4176","position":10,"is_corresponding":false},{"id":291787,"name":"Lindsay A. Becker","orcid":"0000-0003-3034-6742","position":11,"is_corresponding":false},{"id":107041,"name":"Steven P. Gygi","orcid":"0000-0001-7626-0034","position":12,"is_corresponding":false},{"id":107331,"name":"Rohit V. Pappu","orcid":"0000-0003-2568-1378","position":13,"is_corresponding":false},{"id":44859,"name":"Clifford P. Brangwynne","orcid":"0000-0002-1350-9960","position":14,"is_corresponding":false},{"id":23989,"name":"Cigall Kadoch","orcid":"0000-0002-4058-5985","position":15,"is_corresponding":false},{"id":110488,"name":"Ajinkya Patil","orcid":"0000-0003-1080-1146","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":null,"created_at":"2026-07-19T01:06:25.560098Z","pmid":"37788668","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}