{"doi":"10.1016/j.cell.2023.03.031","title":"A tissue injury sensing and repair pathway distinct from host pathogen defense","abstract":"Pathogen infection and tissue injury are universal insults that disrupt homeostasis. Innate immunity senses microbial infections and induces cytokines/chemokines to activate resistance mechanisms. Here, we show that, in contrast to most pathogen-induced cytokines, interleukin-24 (IL-24) is predominately induced by barrier epithelial progenitors after tissue injury and is independent of microbiome or adaptive immunity. Moreover, Il24 ablation in mice impedes not only epidermal proliferation and re-epithelialization but also capillary and fibroblast regeneration within the dermal wound bed. Conversely, ectopic IL-24 induction in the homeostatic epidermis triggers global epithelial-mesenchymal tissue repair responses. Mechanistically, Il24 expression depends upon both epithelial IL24-receptor/STAT3 signaling and hypoxia-stabilized HIF1α, which converge following injury to trigger autocrine and paracrine signaling involving IL-24-mediated receptor signaling and metabolic regulation. Thus, parallel to innate immune sensing of pathogens to resolve infections, epithelial stem cells sense injury signals to orchestrate IL-24-mediated tissue repair.","journal":"Cell","year":2023,"id":316464,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":307282,"name":"Yun Ha Hur","orcid":"0000-0002-8885-4961","position":1,"is_corresponding":false},{"id":1009893,"name":"Xin Cai","orcid":"0000-0002-5300-9733","position":2,"is_corresponding":false},{"id":572645,"name":"Qian Cong","orcid":"0000-0002-8909-0414","position":3,"is_corresponding":false},{"id":550888,"name":"Yihao Yang","orcid":"0000-0002-9229-0054","position":4,"is_corresponding":false},{"id":648171,"name":"Chiwei Xu","orcid":"0000-0003-4967-4949","position":5,"is_corresponding":false},{"id":295160,"name":"Angelina M. Bilate","orcid":"0000-0003-4575-786X","position":6,"is_corresponding":false},{"id":1009894,"name":"Kevin Andrew Uy Gonzales","orcid":"0000-0001-7418-965X","position":7,"is_corresponding":false},{"id":850103,"name":"Sara Martina Parigi","orcid":"0000-0002-4788-3571","position":8,"is_corresponding":false},{"id":618113,"name":"Christopher Cowley","orcid":"0000-0002-7901-9892","position":9,"is_corresponding":false},{"id":268086,"name":"Brian Hurwitz","orcid":"0000-0002-1948-6317","position":10,"is_corresponding":false},{"id":286649,"name":"Ji‐Dung Luo","orcid":"0000-0003-0150-1440","position":11,"is_corresponding":false},{"id":233001,"name":"Tiffany Tseng","orcid":"0000-0003-3069-3824","position":12,"is_corresponding":false},{"id":268085,"name":"Shiri Gur‐Cohen","orcid":"0000-0002-6372-2284","position":13,"is_corresponding":false},{"id":1010374,"name":"Megan Sribour","orcid":null,"position":14,"is_corresponding":false},{"id":108222,"name":"Tatiana Omelchenko","orcid":"0000-0003-2700-6309","position":15,"is_corresponding":false},{"id":254980,"name":"John M. Levorse","orcid":"0000-0002-6570-9796","position":16,"is_corresponding":false},{"id":231064,"name":"H. Amalia Pasolli","orcid":"0000-0003-3899-3530","position":17,"is_corresponding":false},{"id":611838,"name":"Craig B. Thompson","orcid":"0000-0003-3580-2751","position":18,"is_corresponding":false},{"id":66190,"name":"Daniel Mucida","orcid":"0000-0002-0000-0452","position":19,"is_corresponding":false},{"id":104382,"name":"Elaine Fuchs","orcid":"0000-0002-0978-5137","position":20,"is_corresponding":false},{"id":1009892,"name":"Siqi Liu","orcid":"0000-0002-2767-641X","position":0,"is_corresponding":true}],"reference_count":101,"raw_metadata":null,"created_at":"2026-07-19T01:06:38.213358Z","pmid":"37098344","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}