{"doi":"10.1016/j.cell.2022.12.038","title":"Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria","abstract":"Inborn errors of human IFN-γ-dependent macrophagic immunity underlie mycobacterial diseases, whereas inborn errors of IFN-α/β-dependent intrinsic immunity underlie viral diseases. Both types of IFNs induce the transcription factor IRF1. We describe unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens. These children have no history of severe viral disease, despite exposure to many viruses, including SARS-CoV-2, which is life-threatening in individuals with impaired IFN-α/β immunity. In leukocytes or fibroblasts stimulated in vitro, IRF1-dependent responses to IFN-γ are, both quantitatively and qualitatively, much stronger than those to IFN-α/β. Moreover, IRF1-deficient mononuclear phagocytes do not control mycobacteria and related pathogens normally when stimulated with IFN-γ. By contrast, IFN-α/β-dependent intrinsic immunity to nine viruses, including SARS-CoV-2, is almost normal in IRF1-deficient fibroblasts. Human IRF1 is essential for IFN-γ-dependent macrophagic immunity to mycobacteria, but largely redundant for IFN-α/β-dependent antiviral immunity.","journal":"Cell","year":2023,"id":315974,"datarank":0.7242470605953454,"base_score":4.8283137373023015,"endowment":4.8283137373023015,"self_citation_contribution":0.7242470605953454,"citation_network_contribution":0.0,"self_endowment_contribution":0.7242470605953454,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":124,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104481,"name":"Anna‐Lena Neehus","orcid":"0000-0002-8573-6820","position":1,"is_corresponding":false},{"id":104148,"name":"Jérémy Manry","orcid":"0000-0001-5998-2051","position":2,"is_corresponding":false},{"id":104165,"name":"Rui Yang","orcid":"0000-0003-4427-2158","position":3,"is_corresponding":false},{"id":104161,"name":"Jérémie Le Pen","orcid":"0000-0001-7025-9526","position":4,"is_corresponding":false},{"id":862256,"name":"Wassim Daher","orcid":"0000-0001-9026-5333","position":5,"is_corresponding":false},{"id":104460,"name":"Zhiyong Liu","orcid":"0000-0001-6473-348X","position":6,"is_corresponding":false},{"id":227127,"name":"Yi‐Hao Chan","orcid":"0000-0003-0329-238X","position":7,"is_corresponding":false},{"id":1019216,"name":"Natalia Tahuil","orcid":null,"position":8,"is_corresponding":false},{"id":1018471,"name":"Özden Türel","orcid":"0000-0002-6535-4147","position":9,"is_corresponding":false},{"id":550822,"name":"Mathieu Bourgey","orcid":"0000-0002-8432-834X","position":10,"is_corresponding":false},{"id":104463,"name":"Masato Ogishi","orcid":"0000-0003-2421-7389","position":11,"is_corresponding":false},{"id":478718,"name":"Jean‐Marc Doisne","orcid":"0000-0001-6714-1308","position":12,"is_corresponding":false},{"id":1018472,"name":"Helena M. 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