{"doi":"10.1016/j.cell.2022.09.010","title":"Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex","abstract":"Realizing the full utility of brain organoids to study human development requires understanding whether organoids precisely replicate endogenous cellular and molecular events, particularly since acquisition of cell identity in organoids can be impaired by abnormal metabolic states. We present a comprehensive single-cell transcriptomic, epigenetic, and spatial atlas of human cortical organoid development, comprising over 610,000 cells, from generation of neural progenitors through production of differentiated neuronal and glial subtypes. We show that processes of cellular diversification correlate closely to endogenous ones, irrespective of metabolic state, empowering the use of this atlas to study human fate specification. We define longitudinal molecular trajectories of cortical cell types during organoid development, identify genes with predicted human-specific roles in lineage establishment, and uncover early transcriptional diversity of human callosal neurons. The findings validate this comprehensive atlas of human corticogenesis in vitro as a resource to prime investigation into the mechanisms of human cortical development.","journal":"Cell","year":2022,"id":9692,"datarank":4.140850218349657,"base_score":5.3612921657094255,"endowment":5.3612921657094255,"self_citation_contribution":0.8041938248564139,"citation_network_contribution":3.336656393493243,"self_endowment_contribution":0.8041938248564139,"citer_contribution":3.336656393493243,"corpus_percentile":69.97558991049634,"corpus_rank":370,"citation_count":229,"citer_count":187,"citers_with_citation_signal":155,"citers_with_endowment":155,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8912,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-09-01","fair_score":38.0,"fair_percentile":19.17326297273527,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":54474,"name":"Amanda J. 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Levin","orcid":"0000-0002-0170-3598","position":17,"is_corresponding":false},{"id":2734,"name":"Paola Arlotta","orcid":"0000-0003-2184-2277","position":18,"is_corresponding":false},{"id":3630,"name":"Jason D. Buenrostro","orcid":"0000-0001-9958-3987","position":19,"is_corresponding":false},{"id":54473,"name":"Ana Uzquiano","orcid":"0000-0003-0696-6087","position":0,"is_corresponding":true}],"reference_count":117,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":"36179669","pmcid":"PMC9990683","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":74.0,"fair_a":53.0,"fair_i":5.0,"fair_r":20.0,"fair_zscore":-0.6523,"fair_rationale":{"fair_score":38.0,"has_llm":true,"dimensions":{"F":{"name":"Findable","score":74.0,"criteria":[{"key":"f_has_doi","label":"Has a persistent DOI","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"DOI present","rationale":null},{"key":"f_repository_presence","label":"Indexed in repositories / literature DBs","kind":"deterministic","weight":1.0,"fraction":1.0,"signal":"datacite=0, pmcid=True, pmid=True","rationale":null},{"key":"f_persistent_ids","label":"Resolvable scholarly identifiers (OpenAlex)","kind":"deterministic","weight":0.5,"fraction":0.0,"signal":"no OpenAlex id","rationale":null},{"key":"f_metadata_richness","label":"Rich, machine-readable metadata","kind":"llm","weight":1.0,"fraction":0.5,"signal":null,"rationale":"The paper mentions a comprehensive single-cell transcriptomic, epigenetic, and spatial atlas with over 610,000 cells, but does not specify machine-readable metadata formats or standards like structured data repositories or persistent identifiers."}]},"A":{"name":"Accessible","score":53.0,"criteria":[{"key":"a_open_access","label":"Open Access / files deposited","kind":"deterministic","weight":1.5,"fraction":1.0,"signal":"Open Access","rationale":null},{"key":"a_retrievable","label":"Free full text retrievable","kind":"deterministic","weight":1.0,"fraction":0.0,"signal":"0 OA location(s)","rationale":null},{"key":"a_access_protocol","label":"Clear 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