{"doi":"10.1016/j.cell.2022.03.024","title":"Vaccine protection against the SARS-CoV-2 Omicron variant in macaques","abstract":"The rapid spread of the SARS-CoV-2 Omicron (B.1.1.529) variant, including in highly vaccinated populations, has raised important questions about the efficacy of current vaccines. In this study, we show that the mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaques. We vaccinated 30 macaques with homologous and heterologous prime-boost regimens with BNT162b2 and Ad26.COV2.S. Following Omicron challenge, vaccinated macaques demonstrated rapid control of virus in bronchoalveolar lavage, and most vaccinated animals also controlled virus in nasal swabs. However, 4 vaccinated animals that had moderate Omicron-neutralizing antibody titers and undetectable Omicron CD8+ T cell responses failed to control virus in the upper respiratory tract. Moreover, virologic control correlated with both antibody and T cell responses. These data suggest that both humoral and cellular immune responses contribute to vaccine protection against a highly mutated SARS-CoV-2 variant.","journal":"Cell","year":2022,"id":235114,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":85,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106716,"name":"Jingyou Yu","orcid":"0000-0002-0775-6623","position":1,"is_corresponding":false},{"id":106719,"name":"Katherine McMahan","orcid":"0000-0002-3933-0539","position":2,"is_corresponding":false},{"id":106747,"name":"Catherine Jacob-Dolan","orcid":"0000-0001-6641-0342","position":3,"is_corresponding":false},{"id":218111,"name":"Jinyan Liu","orcid":"0000-0003-0504-2181","position":4,"is_corresponding":false},{"id":106746,"name":"Xuan He","orcid":"0000-0002-9448-4426","position":5,"is_corresponding":false},{"id":630509,"name":"David Hope","orcid":"0000-0001-5654-1744","position":6,"is_corresponding":false},{"id":618176,"name":"Tochi Anioke","orcid":"0000-0003-4523-4997","position":7,"is_corresponding":false},{"id":630511,"name":"Julia Barrett","orcid":"0000-0002-5857-3632","position":8,"is_corresponding":false},{"id":805687,"name":"Benjamin Chung","orcid":"0000-0001-9295-2161","position":9,"is_corresponding":false},{"id":805688,"name":"Nicole P. 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