{"doi":"10.1016/j.cell.2022.01.029","title":"T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals","abstract":"The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from antibody responses, although the extent to which these substitutions in spike and non-spike proteins affect T cell recognition is unknown. In this study, we show that T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. However, we also identify a subset of individuals (∼21%) with a >50% reduction in T cell reactivity to the Omicron spike. Evaluation of functional CD4+ and CD8+ memory T cell responses confirmed these findings and revealed that reduced recognition to Omicron spike is primarily observed within the CD8+ T cell compartment potentially due to escape from HLA binding. Booster vaccination enhanced T cell responses to Omicron spike. In contrast to neutralizing immunity, these findings suggest preservation of T cell responses to the Omicron variant, although with reduced reactivity in some individuals.","journal":"Cell","year":2022,"id":232127,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":260,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463010,"name":"Anusha Nathan","orcid":"0000-0002-4418-1005","position":1,"is_corresponding":false},{"id":364637,"name":"Clarety Kaseke","orcid":"0000-0001-9293-6508","position":2,"is_corresponding":false},{"id":804626,"name":"Cristhian Berrios","orcid":null,"position":3,"is_corresponding":false},{"id":108426,"name":"Ashok Khatri","orcid":"0000-0003-4740-3846","position":4,"is_corresponding":false},{"id":842925,"name":"Shawn Choi","orcid":null,"position":5,"is_corresponding":false},{"id":539223,"name":"Matthew A. Getz","orcid":"0000-0002-4172-2187","position":6,"is_corresponding":false},{"id":365661,"name":"Rhoda Tano-Menka","orcid":null,"position":7,"is_corresponding":false},{"id":639838,"name":"Onosereme Ofoman","orcid":null,"position":8,"is_corresponding":false},{"id":841633,"name":"Alton C. Gayton","orcid":"0000-0002-2411-0621","position":9,"is_corresponding":false},{"id":284589,"name":"Fernando Senjobe","orcid":"0000-0003-4322-6571","position":10,"is_corresponding":false},{"id":441586,"name":"Zezhou Zhao","orcid":"0000-0003-4792-6073","position":11,"is_corresponding":false},{"id":614444,"name":"Kerri St. Denis","orcid":"0000-0002-6324-7890","position":12,"is_corresponding":false},{"id":108252,"name":"Evan C. Lam","orcid":"0000-0002-5556-2559","position":13,"is_corresponding":false},{"id":37727,"name":"Mary Carrington","orcid":"0000-0002-2692-2180","position":14,"is_corresponding":false},{"id":108251,"name":"Wilfredo F. García-Beltrán","orcid":"0000-0002-7109-0504","position":15,"is_corresponding":false},{"id":108262,"name":"Alejandro B. Balazs","orcid":"0000-0002-1767-3944","position":16,"is_corresponding":false},{"id":108341,"name":"Bruce D. Walker","orcid":"0000-0001-6122-9245","position":17,"is_corresponding":false},{"id":28992,"name":"A. John Iafrate","orcid":"0000-0002-7888-4067","position":18,"is_corresponding":false},{"id":234874,"name":"Gaurav D. Gaiha","orcid":"0000-0001-6875-4472","position":19,"is_corresponding":false},{"id":292648,"name":"Vivek Naranbhai","orcid":"0000-0003-4281-8882","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T00:21:12.348693Z","pmid":"35202566","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}