{"doi":"10.1016/j.cell.2020.02.058","title":"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein","abstract":"The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S<sub>1</sub>/S<sub>2</sub> subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination.","journal":"Cell","year":2020,"id":12279,"datarank":18.180452650533002,"base_score":9.111403624116159,"endowment":9.111403624116159,"self_citation_contribution":1.366710543617424,"citation_network_contribution":16.81374210691558,"self_endowment_contribution":1.366710543617424,"citer_contribution":16.81374210691558,"corpus_percentile":92.2,"corpus_rank":1497,"citation_count":9057,"citer_count":184,"citers_with_citation_signal":184,"citers_with_endowment":184,"datacite_reuse_total":0,"is_dataset":false,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-04-01","authors":[{"id":97047,"name":"Young-Jun Park","orcid":null,"position":1,"is_corresponding":false},{"id":97048,"name":"M. Alejandra Tortorici","orcid":"0000-0002-2260-2577","position":2,"is_corresponding":false},{"id":97049,"name":"Abigail Wall","orcid":"0000-0001-8198-2138","position":3,"is_corresponding":false},{"id":97050,"name":"Andrew T. McGuire","orcid":"0000-0003-1841-6859","position":4,"is_corresponding":false},{"id":97051,"name":"David Veesler","orcid":"0000-0002-6019-8675","position":5,"is_corresponding":false},{"id":97052,"name":"Young‐Jun Park","orcid":"0000-0003-2901-6949","position":6,"is_corresponding":false},{"id":97046,"name":"Alexandra C. Walls","orcid":"0000-0002-9636-8330","position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}