{"doi":"10.1016/j.cell.2017.06.016","title":"IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment","abstract":"Homeostatic programs balance immune protection and self-tolerance. Such mechanisms likely impact autoimmunity and tumor formation, respectively. How homeostasis is maintained and impacts tumor surveillance is unknown. Here, we find that different immune mononuclear phagocytes share a conserved steady-state program during differentiation and entry into healthy tissue. IFNγ is necessary and sufficient to induce this program, revealing a key instructive role. Remarkably, homeostatic and IFNγ-dependent programs enrich across primary human tumors, including melanoma, and stratify survival. Single-cell RNA sequencing (RNA-seq) reveals enrichment of homeostatic modules in monocytes and DCs from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNγ. SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regulatory role. These findings link immune homeostasis to key determinants of anti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumor microenvironment.","journal":"Cell","year":2017,"id":1666,"datarank":8.409023717452374,"base_score":5.2574953720277815,"endowment":5.2574953720277815,"self_citation_contribution":0.7886243058041673,"citation_network_contribution":7.620399411648207,"self_endowment_contribution":0.7886243058041673,"citer_contribution":7.620399411648207,"corpus_percentile":null,"corpus_rank":null,"citation_count":191,"citer_count":162,"citers_with_citation_signal":154,"citers_with_endowment":154,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2017-06-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":18921,"name":"Mayte Suárez-Fariñas","orcid":null,"position":1,"is_corresponding":false},{"id":5593,"name":"Benjamin Izar","orcid":"0000-0003-2379-6702","position":2,"is_corresponding":false},{"id":18923,"name":"Ruth Dannenfelser","orcid":"0000-0002-8766-6424","position":4,"is_corresponding":false},{"id":2735,"name":"Itay Tirosh","orcid":"0000-0001-5477-2987","position":5,"is_corresponding":false},{"id":18924,"name":"Yong Liu","orcid":"0000-0002-0574-2877","position":6,"is_corresponding":false},{"id":18925,"name":"Qian Zhu","orcid":"0000-0001-7062-8221","position":7,"is_corresponding":false},{"id":18926,"name":"K. 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