{"doi":"10.1016/j.cell.2013.07.015","title":"Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle","abstract":null,"journal":"Cell","year":2013,"id":588793,"datarank":8.22346188588653,"base_score":5.501258210544727,"endowment":5.501258210544727,"self_citation_contribution":0.8251887315817092,"citation_network_contribution":7.398273154304821,"self_endowment_contribution":0.8251887315817092,"citer_contribution":7.398273154304821,"corpus_percentile":null,"corpus_rank":null,"citation_count":244,"citer_count":200,"citers_with_citation_signal":182,"citers_with_endowment":182,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1506401,"name":"Takeshi Noda","orcid":null,"position":1,"is_corresponding":false},{"id":1506402,"name":"Dafna M. Abelson","orcid":null,"position":2,"is_corresponding":false},{"id":107104,"name":"Peter Halfmann","orcid":"0000-0002-1648-1625","position":3,"is_corresponding":false},{"id":1506403,"name":"Malcolm R. Wood","orcid":null,"position":4,"is_corresponding":false},{"id":107110,"name":"Yoshihiro Kawaoka","orcid":"0000-0001-5061-8296","position":5,"is_corresponding":false},{"id":1506404,"name":"Erica Ollmann Saphire","orcid":null,"position":6,"is_corresponding":false},{"id":1506400,"name":"Zachary A. Bornholdt","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Structural Rearrangement of Ebola Virus VP40 Begets Multiple Functions in the Virus Life Cycle","abstract":"Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry, and cellular microscopy that VP40 rearranges into different structures, each with a distinct function required for the ebolavirus life cycle. A butterfly-shaped VP40 dimer traffics to the cellular membrane. Once there, electrostatic interactions trigger rearrangement of the polypeptide into a linear hexamer. These hexamers construct a multilayered, filamentous matrix structure that is critical for budding and resembles tomograms of authentic virions. A third structure of VP40, formed by a different rearrangement, is not involved in virus assembly but instead uniquely binds RNA to regulate viral transcription inside infected cells. These results provide a functional model for ebolavirus matrix assembly and the other roles of VP40 in the virus life cycle and demonstrate how a single wild-type, unmodified polypeptide can assemble into different structures for different functions.","is_dataset_classified":null,"base_score":5.501258210544727,"endowment":5.501258210544727,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23953110","pmcid":"PMC4138722","openalex_id":"https://openalex.org/W2138741496","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R43 AI1088843","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"2T32AI007244","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R43 AI088843","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"U54 AI057153","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"T32 AI007244","title":null},{"funder_name":"National Institutes of Health","grant_id":"2T32AI007244-21","title":"Immunology Training"},{"funder_name":"National Institutes of Health","grant_id":"5U54AI057153-02","title":"Bioterrorism: Molecular Analysis and Intervention"}],"total_grants":7,"fwci":13.5297,"citation_percentile":0.99340619,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":24},{"year":2015,"count":25},{"year":2016,"count":27},{"year":2017,"count":16},{"year":2018,"count":26},{"year":2019,"count":20},{"year":2020,"count":24},{"year":2021,"count":16},{"year":2022,"count":18},{"year":2023,"count":8},{"year":2024,"count":17},{"year":2025,"count":12},{"year":2026,"count":7}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0092867413008866/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0092867413008866/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867413008866?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867413008866?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cell.2013.07.015","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23953110","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4138722","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.cell.2013.07.015","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cell.2013.07.015","host_type":""}],"fields_of_study":["Viral Infections and Outbreaks Research","Hepatitis B Virus Studies","Viral gastroenteritis research and epidemiology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Crystallography, X-Ray","Dimerization","Ebolavirus","Models, Molecular","Mutagenesis","Point Mutation","Viral Matrix Proteins","Virus Assembly","Virus Release"],"mesh_terms":["Models, Molecular","Viral Matrix Proteins","Mutagenesis","Point Mutation","Crystallography, X-Ray","Virus Assembly","Dimerization","Ebolavirus","Virus Release"],"keywords":["Biology","Ebola virus","Virus","Virology","Viral life cycle","VP40","Cell biology","Viral replication","Models, Molecular","Biochemistry, Genetics and Molecular Biology(all)","Virus Assembly","Crystallography, X-Ray","Ebolavirus","Viral Matrix Proteins","Mutagenesis","Point Mutation","Dimerization","Virus Release"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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