{"doi":"10.1016/j.cell.2005.09.034","title":"Chromosome Sites Play Dual Roles to Establish Homologous Synapsis during Meiosis in C. elegans","abstract":null,"journal":"Cell","year":2005,"id":601377,"datarank":0.878689973172519,"base_score":5.857933154483459,"endowment":5.857933154483459,"self_citation_contribution":0.878689973172519,"citation_network_contribution":0.0,"self_endowment_contribution":0.878689973172519,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":349,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":482877,"name":"Carolyn M. Phillips","orcid":"0000-0002-6228-6468","position":1,"is_corresponding":false},{"id":63528,"name":"Needhi Bhalla","orcid":"0000-0002-6859-0073","position":2,"is_corresponding":false},{"id":1542010,"name":"Pinky Weiser","orcid":null,"position":3,"is_corresponding":false},{"id":314344,"name":"Anne M. Villeneuve","orcid":"0000-0001-5193-2076","position":4,"is_corresponding":false},{"id":23409,"name":"Abby F. Dernburg","orcid":"0000-0001-8037-1079","position":5,"is_corresponding":false},{"id":783844,"name":"Amy J. MacQueen","orcid":"0000-0002-0919-7538","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Chromosome Sites Play Dual Roles to Establish Homologous Synapsis during Meiosis in C. elegans","abstract":"We have investigated the role of pairing centers (PCs), cis-acting sites required for accurate segregation of homologous chromosomes during meiosis in C. elegans. We find that these sites play two distinct roles that contribute to proper segregation. Chromosomes lacking PCs usually fail to synapse and also lack a synapsis-independent stabilization activity. The presence of a PC on just one copy of a chromosome pair promotes synapsis but does not support synapsis-independent pairing stabilization, indicating that these functions are separable. Once initiated, synapsis is highly processive, even between nonhomologous chromosomes of disparate lengths, elucidating how translocations suppress meiotic recombination in C. elegans. These findings suggest a multistep pathway for chromosome synapsis in which PCs impart selectivity and efficiency through a \"kinetic proofreading\" mechanism. We speculate that concentration of these activities at one region per chromosome may have coevolved with the loss of a point centromere to safeguard karyotype stability.","is_dataset_classified":null,"base_score":5.857933154483459,"endowment":5.857933154483459,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16360034","pmcid":"PMC4435800","openalex_id":"https://openalex.org/W2049427149","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM53804","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM655591","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM053804","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM067408","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"F32 GM067408","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM065591","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM053804-17","title":"Meiotic Chromosome Segregation in C. elegans"}],"total_grants":7,"fwci":3.6755,"citation_percentile":0.94506518,"influential_citations":0,"citation_trend":[{"year":2012,"count":10},{"year":2013,"count":20},{"year":2014,"count":10},{"year":2015,"count":13},{"year":2016,"count":18},{"year":2017,"count":19},{"year":2018,"count":14},{"year":2019,"count":21},{"year":2020,"count":18},{"year":2021,"count":26},{"year":2022,"count":18},{"year":2023,"count":27},{"year":2024,"count":17},{"year":2025,"count":21},{"year":2026,"count":10}],"oa_status":"bronze","license":"Elsevier Non-Commercial","oa_locations":[{"url":"http://www.cell.com/article/S0092867405010408/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S0092867405010408/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867405010408?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0092867405010408?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.cell.2005.09.034","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16360034","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4435800","host_type":"repository"},{"url":"http://dx.doi.org/10.1016/j.cell.2005.09.034","host_type":""},{"url":"https://dx.doi.org/10.1016/j.cell.2005.09.034","host_type":""}],"fields_of_study":["Genetics, Aging, and Longevity in Model Organisms","DNA Repair Mechanisms","Mitochondrial Function and Pathology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Chromosome Deletion","Chromosomes","Crossing Over, Genetic","Female","Heterozygote","Male","Meiosis","Microscopy, Fluorescence","Models, Genetic","Recombination, Genetic","Disorders of Sex Development","Synaptonemal Complex","X Chromosome","Caenorhabditis elegans","Chromosome Painting","Chromosome Pairing","Caenorhabditis elegans Proteins","Meiotic Prophase I"],"keywords":["Synapsis","Biology","Synaptonemal complex","Homologous chromosome","Genetics","Chromosomal crossover","Meiosis","Chromosome segregation","Chromosome","Gene","Male","Recombination, Genetic","Heterozygote","X Chromosome","Models, Genetic","Biochemistry, Genetics and Molecular Biology(all)","Disorders of Sex Development","Chromosomes","Chromosome Painting","Chromosome Pairing","Microscopy, Fluorescence","Animals","Female","Crossing Over, Genetic","Chromosome Deletion","Meiotic Prophase I","Caenorhabditis elegans","Caenorhabditis elegans Proteins"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T16:07:11.430151Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}