{"doi":"10.1016/j.ceca.2024.102888","title":"Anoctamins in epithelial transport","abstract":null,"journal":"Cell Calcium","year":2024,"id":634938,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1647009,"name":"Jiraporn Ousingsawat","orcid":null,"position":1,"is_corresponding":false},{"id":162076,"name":"Rainer Schreiber","orcid":null,"position":2,"is_corresponding":false},{"id":424064,"name":"Karl Kunzelmann","orcid":"0000-0002-4583-7037","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Anoctamins in epithelial transport","abstract":"Plasma membrane localized anoctamin 1, 2 and 6 (TMEM16A, B, F) have been examined in great detail with respect to structure and function, but much less is known about the other seven intracellular members of this exciting family of proteins. This is probably due to their limited accessibility in intracellular membranous compartments, such as the endoplasmic reticulum (ER) or endosomes. However, these so-called intracellular anoctamins are also found in the plasma membrane (PM) which adds to the confusion regarding their cellular role. Probably all intracellular anoctamins except of ANO8 operate as intracellular phospholipid (PL) scramblases, allowing for Ca<sup>2+</sup>-activated, passive transport of phospholipids like phosphatidylserine between both membrane leaflets. Probably all of them also conduct ions, which is probably part of their physiological function. In this brief overview, we summarize key findings on the biological functions of ANO3, 4, 5, 7, 8, 9 and 10 (TMEM16C, D, E, G, H, J, K) that are gradually coming to light. Compartmentalized regulation of intracellular Ca<sup>2+</sup> signals, tethering of the ER to specific PM contact sites, and control of intracellular vesicular trafficking appear to be some of the functions of intracellular anoctamins, while loss of function and abnormal expression are the cause for various diseases.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38657371","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"509149993","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"A3","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1016/j.ceca.2024.102888","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0143416024000460?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0143416024000460?httpAccept=text/plain","host_type":"publisher"},{"url":"https://epub.uni-regensburg.de/58394/1/1-s2.0-S0143416024000460-main.pdf","host_type":"repository"},{"url":"https://doi.org/10.5283/epub.58394","host_type":"repository"},{"url":"https://dx.doi.org/10.5283/epub.58394","host_type":""},{"url":"https://epub.uni-regensburg.de/58394/","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Cell Membrane","Animals","Humans","Structure-Activity Relationship","Anoctamins"],"keywords":["Calcium signaling","Dystonia","Chronic Kidney Disease","Ano5","Ano3","Ano9","Tmem16e","Tmem16j","Tmem16k","Ano10","Tmem16d","Ano7","Ano8","Tmem16c","Tmem16g","Tmem16h","Ano4","ddc:610","TMEM16C TMEM16D TMEM16E TMEM16G TMEM16H TMEM16J TMEM16K ANO3 ANO4 ANO5 ANO7 ANO8; ANO9;ANO10; Dystonia; Chronic kidney disease Calcium signaling","610 Medizin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:24:29.177283Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}