{"doi":"10.1016/j.ceb.2025.102570","title":"Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity","abstract":"The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (Na V ) and potassium (K V ) channels in neurons. In neocortical pyramidal neurons, Na V 1.2 and Na V 1.6 are key at the axon initial segment (AIS) and nodes of Ranvier (noR), driving AP initiation and propagation. Na V 1.2 also supports AP backpropagation in the soma and dendrites. Ankyrin-G anchors these channels at the AIS and noR, while new findings reveal that ankyrin-B scaffolds Na V 1.2 in dendrites. This review highlights how ankyrins stabilize Na V and K V channels across neuronal domains, ensuring proper function crucial for excitability, synaptic plasticity, and signaling. Recent findings explore how ankyrins differentially localize Na V 1.2 and Na V 1.6, with implications for understanding neurological disorders linked to disrupted channel localization.","journal":"Current Opinion in Cell Biology","year":2025,"id":531612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.945,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463650,"name":"Paul M. Jenkins","orcid":"0000-0002-4207-5823","position":1,"is_corresponding":false},{"id":989104,"name":"Carina C. Elvira","orcid":"0000-0002-0376-364X","position":0,"is_corresponding":true}],"reference_count":74,"raw_metadata":null,"created_at":"2026-07-19T02:51:14.579161Z","pmid":"40674863","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}