{"doi":"10.1016/j.ceb.2022.02.003","title":"Versatile roles for histones in early development","abstract":null,"journal":"Current Opinion in Cell Biology","year":2022,"id":598688,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1534331,"name":"Madeleine G. Brown","orcid":null,"position":1,"is_corresponding":false},{"id":402536,"name":"Amanda A. Amodeo","orcid":"0000-0003-3701-6375","position":2,"is_corresponding":false},{"id":570703,"name":"Yuki Shindo","orcid":"0000-0001-5313-5492","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Versatile roles for histones in early development","abstract":"The nuclear environment changes dramatically over the course of early development. Histones are core chromatin components that play critical roles in regulating gene expression and nuclear architecture. Additionally, the embryos of many species, including Drosophila, Zebrafish, and Xenopus use the availability of maternally deposited histones to time critical early embryonic events including cell cycle slowing and zygotic genome activation. Here, we review recent insights into how histones control early development. We first discuss the regulation of chromatin functions through interaction of histones and transcription factors, incorporation of variant histones, and histone post-translational modifications. We also highlight emerging roles for histones as developmental regulators independent of chromatin association.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35279563","pmcid":"PMC9064922","openalex_id":"https://openalex.org/W35279563","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"P20 GM113132","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.00589217,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"https://doi.org/10.15223/policy-004","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9064922","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S095506742200014X?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S095506742200014X?httpAccept=text/plain","host_type":"publisher"},{"url":"http://ci.nii.ac.jp/naid/110007378904","host_type":"journal"}],"fields_of_study":["Genomics and Chromatin Dynamics"],"mesh_terms":["Zygote","Cell Nucleus","Chromatin","Animals","Zebrafish","Drosophila","Histones","Gene Expression Regulation, Developmental"],"keywords":["Business","Political science","Computer science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T16:06:57.173968Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}