{"doi":"10.1016/j.ceb.2020.10.004","title":"Microtubule nucleation: The waltz between γ-tubulin ring complex and associated proteins","abstract":null,"journal":"Current Opinion in Cell Biology","year":2021,"id":648688,"datarank":1.7772062125601025,"base_score":4.343805421853684,"endowment":4.343805421853684,"self_citation_contribution":0.6515708132780527,"citation_network_contribution":1.1256353992820498,"self_endowment_contribution":0.6515708132780527,"citer_contribution":1.1256353992820498,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":75,"citers_with_citation_signal":51,"citers_with_endowment":51,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1690712,"name":"Martin Würtz","orcid":"0000-0002-4504-4723","position":1,"is_corresponding":false},{"id":1690713,"name":"Erik Zupa","orcid":null,"position":2,"is_corresponding":false},{"id":148096,"name":"Stefan Pfeffer","orcid":null,"position":3,"is_corresponding":false},{"id":201986,"name":"Elmar Schiebel","orcid":"0000-0002-3683-247X","position":4,"is_corresponding":false},{"id":231779,"name":"Peng Liu","orcid":"0000-0001-6965-8001","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Microtubule nucleation: The waltz between γ-tubulin ring complex and associated proteins","abstract":"Microtubules are essential cytoskeletal elements assembled from αβ-tubulin dimers. In high eukaryotes, microtubule nucleation, the de novo assembly of a microtubule from its minus end, is initiated by the γ-tubulin ring complex (γ-TuRC). Despite many years of research, the structural and mechanistic principles of the microtubule nucleation machinery remained poorly understood. Only recently, cryoelectron microscopy studies uncovered the molecular organization and potential activation mechanisms of γ-TuRC. In vitro assays further deciphered the spatial and temporal cooperation between γ-TuRC and additional factors, for example, the augmin complex, the phase separation protein TPX2, and the microtubule polymerase XMAP215. These breakthroughs deepen our understanding of microtubule nucleation mechanisms and will link the assembly of individual microtubules to the organization of cellular microtubule networks.","is_dataset_classified":null,"base_score":4.343805421853684,"endowment":4.343805421853684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33190097","pmcid":null,"openalex_id":"https://openalex.org/W3101998202","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"","title":null}],"total_grants":2,"fwci":4.8506,"citation_percentile":0.96466415,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":16},{"year":2022,"count":13},{"year":2023,"count":18},{"year":2024,"count":9},{"year":2025,"count":10},{"year":2026,"count":9}],"oa_status":"closed","license":"Elsevier TDM","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0955067420301393?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0955067420301393?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ceb.2020.10.004","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33190097","host_type":"repository"},{"url":"https://dx.doi.org/10.1016/j.ceb.2020.10.004","host_type":""}],"fields_of_study":["Microtubule and mitosis dynamics","Photosynthetic Processes and Mechanisms","Protist diversity and phylogeny","0301 basic medicine","03 medical and health sciences","Animals","Cryoelectron Microscopy","Humans","Microtubule-Associated Proteins","Microtubule-Organizing Center","Microtubules","Polymerization","Tubulin"],"mesh_terms":["Animals","Humans","Microtubule-Associated Proteins","Microtubules","Tubulin","Cryoelectron Microscopy","Microtubule-Organizing Center","Polymerization"],"keywords":["Microtubule nucleation","Microtubule","Tubulin","Biology","Cell biology","Cytoskeleton","Microtubule organizing center","Microtubule-associated protein","Nucleation","Biophysics","Centrosome","Chemistry","Biochemistry","Cell","Cell cycle","Tpx2","Xmap215","Augmin Complex","Branching Microtubule Nucleation","Γ-tubulin Ring Complex (Γ-turc)","Cryoelectron Microscopy","Animals","Humans","Microtubule-Associated Proteins","Microtubules","Microtubule-Organizing Center","Polymerization"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:52:29.969012Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}