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Fibronectin is a key constituent of the pericellular ECM, forming essential connections between cell surface integrin receptors and structural components of the ECM. Recent studies using vertebrate models, conditional gene knockouts, tissue explants, and cell culture systems have identified developmental processes that depend on fibronectin and its receptor α5β1 integrin. We describe requirements for fibronectin matrix in the cardiovascular system, somite and precartilage development, and epithelial-mesenchymal transition. Information about molecular mechanisms shows the importance of fibronectin and integrins during tissue morphogenesis and cell differentiation, as well as their cooperation with growth factors to mediate changes in cell behaviors.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27062478","pmcid":"PMC5055409","openalex_id":"https://openalex.org/W2330163142","authors":[],"funders":[{"funder_name":"NIH","grant_id":"CA160611","title":null},{"funder_name":"NIH","grant_id":"EB001046","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"F32 DK109622","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA160611","title":null},{"funder_name":"NIBIB NIH HHS","grant_id":"P41 EB001046","title":null}],"total_grants":5,"fwci":3.3451,"citation_percentile":0.91465091,"influential_citations":0,"citation_trend":[{"year":2016,"count":5},{"year":2017,"count":4},{"year":2018,"count":4},{"year":2019,"count":3},{"year":2020,"count":6},{"year":2021,"count":3},{"year":2022,"count":7},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"green","license":"https://www.elsevier.com/legal/tdmrep-license","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5055409","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5055409","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0955067416300552?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0955067416300552?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ceb.2016.03.014","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27062478","host_type":"repository"}],"fields_of_study":["Cell Adhesion Molecules Research","Cellular Mechanics and Interactions","RNA Research and Splicing","Animals","Cadherins","Cell Differentiation","Extracellular Matrix","Fibronectins","Humans","Morphogenesis","Signal Transduction"],"mesh_terms":["Animals","Cell Differentiation","Extracellular Matrix","Fibronectins","Humans","Morphogenesis","Signal Transduction","Cadherins"],"keywords":["Fibronectin","Extracellular matrix","Biology","Cell biology","Morphogenesis","Integrin","Laminin","Somite","Cellular differentiation","Cell adhesion","Matrix (chemical analysis)","Cell","Genetics","Embryogenesis","Gene","Chemistry","Embryo"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T19:57:22.036860Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}