{"doi":"10.1016/j.ceb.2013.04.011","title":"Assembling a primary cilium","abstract":null,"journal":"Current Opinion in Cell Biology","year":2013,"id":590984,"datarank":6.182233864438516,"base_score":5.062595033026967,"endowment":5.062595033026967,"self_citation_contribution":0.7593892549540452,"citation_network_contribution":5.422844609484471,"self_endowment_contribution":0.7593892549540452,"citer_contribution":5.422844609484471,"corpus_percentile":null,"corpus_rank":null,"citation_count":157,"citer_count":153,"citers_with_citation_signal":127,"citers_with_endowment":127,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":376950,"name":"Brian David Dynlacht","orcid":"0000-0001-9485-512X","position":1,"is_corresponding":false},{"id":875307,"name":"Sehyun Kim","orcid":"0000-0003-0291-6058","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Assembling a primary cilium","abstract":"Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail. The cilium is assembled from mature (mother) centrioles or basal bodies, which serve to nucleate growth of axonemes that give rise to two structurally distinct variants, motile and nonmotile cilia. Whereas motile cilia are typically found in large bundles and beat synchronously to generate fluid flow, primary cilia (with the exception of those found at the embryonic node) are generally immotile and are found as solitary organelles. Remarkably, until recently, the primary cilium was considered a vestigial organelle without apparent biological function. However, research over the past decade has established that the primary cilium is capable of transducing essential signaling information from the extracellular milieu. Defects in the cilium, and the structure from which it arises, the basal body, have been shown to cause a spectrum of diseases, ranging from developmental defects to obesity, diabetes, and cancer. Many of these diseases, or ciliopathies, are manifested as genetic syndromes, such as Joubert syndrome, Bardet-Biedel (BBS), Meckel-Gruber (MKS), and Nephronophthisis (NPHP), illustrating the importance of understanding cilium structure and function and the mechanisms required for its assembly. This review focuses primarily on recent advances in our understanding of the regulatory controls governing the assembly and maintenance of the primary cilium.","is_dataset_classified":null,"base_score":5.062595033026967,"endowment":5.062595033026967,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23747070","pmcid":"PMC3729615","openalex_id":"https://openalex.org/W2011983184","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"R01 HD069647","title":null},{"funder_name":"NICHD NIH HHS","grant_id":"1R01HD069647-01","title":"The Role of CP110 in Ciliogenesis"}],"total_grants":2,"fwci":14.5487,"citation_percentile":0.99222059,"influential_citations":0,"citation_trend":[{"year":2013,"count":4},{"year":2014,"count":21},{"year":2015,"count":23},{"year":2016,"count":21},{"year":2017,"count":18},{"year":2018,"count":15},{"year":2019,"count":9},{"year":2020,"count":9},{"year":2021,"count":10},{"year":2022,"count":4},{"year":2023,"count":9},{"year":2024,"count":3},{"year":2025,"count":8},{"year":2026,"count":2}],"oa_status":"green","license":"Elsevier TDM","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3729615","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3729615","host_type":"repository"},{"url":"https://api.elsevier.com/content/article/PII:S0955067413000744?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0955067413000744?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.ceb.2013.04.011","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23747070","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc3729615?pdf=render","host_type":""},{"url":"https://dx.doi.org/10.1016/j.ceb.2013.04.011","host_type":""}],"fields_of_study":["Genetic and Kidney Cyst Diseases","Microtubule and mitosis dynamics","Genetic Syndromes and Imprinting","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Centrioles","Cilia","Ciliary Motility Disorders","Humans","Microtubules","Signal Transduction"],"mesh_terms":["Animals","Centrioles","Cilia","Ciliary Motility Disorders","Humans","Microtubules","Signal Transduction"],"keywords":["Cilium","Ciliopathies","Biology","Basal body","Motile cilium","Nephronophthisis","Centriole","Ciliogenesis","Ciliopathy","Intraflagellar transport","Joubert syndrome","Cell biology","Organelle","Flagellum","Microtubule","Genetics","Phenotype","Gene","Animals","Humans","Cilia","Microtubules","Centrioles","Ciliary Motility Disorders","Signal Transduction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T13:31:27.183426Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}