{"doi":"10.1016/j.cdnut.2025.107568","title":"Effect of Maternal Moringa oleifera Leaf Supplementation on Maternal and Infant Nutritional Status and Human Milk Output: A Pilot Single-Blinded Cluster-Randomized Trial","abstract":"Background Feeding of human milk enhances infant health and survival over alternative feeding modalities, but early cessation often occurs due to perceived or real insufficient milk supply. Moringa oleifera leaves are nutrient-dense and may increase milk output Objective We investigated the impact of maternal dried moringa leaf powder supplementation (moringa) on milk composition and output and infant and maternal health Methods Breastfeeding mother-infant pairs (n=50) living in Kisumu County, Kenya were cluster-randomized by location to consume moringa (20 g/d) in corn porridge (moringa) or corn porridge alone (control) for 3 months. Milk and maternal/infant blood were collected and 24-hour expressed milk volume evaluated at baseline and 3 months. Maternal and infant anthropometrics were measured monthly. Milk lipid and protein concentrations and maternal and/or infant serum retinol binding protein, ferritin/soluble transferrin receptor, and insulin-like growth factor 1 (IGF-1) concentrations were measured Results Nearly all dyads (n=45, 90%) completed the study. Baseline characteristics were similar between groups. At 3 months, mothers consuming moringa expressed twice as much milk as controls: mean (95% CI) 947 (794, 1113) vs. 618 (486, 763) mL, respectively, p=0.003. Infant serum IGF-1 concentration was greater in the moringa group than controls: 25.2 (21.0, 29.5) vs. 17.8 (13.6, 22.0) ng/mL, respectively, p=0.017. There was no effect of moringa on total milk lipid and protein concentrations, fatty acids, or on infant growth Conclusions In this population, 3 months of maternal moringa consumption was associated with increased expressed milk output and higher circulating infant IGF-1 without impacting infant growth. Additional studies are needed to understand the mechanisms driving these effects and their influence on long-term health. Clinical Trial Registry https://clinicaltrials.gov/ct2/show/NCT04587271 Clinical Trial Registry https://clinicaltrials.gov/ct2/show/NCT04587271 . Trial ID: 58219","journal":"Current Developments in Nutrition","year":2025,"id":532981,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9557,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04587271"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672573,"name":"Patrick Mbullo Owuor","orcid":"0000-0002-4550-2667","position":1,"is_corresponding":false},{"id":942363,"name":"Silvia A. Odhiambo","orcid":"0009-0002-7794-5830","position":2,"is_corresponding":false},{"id":368568,"name":"Jerusha N. Mogaka","orcid":"0000-0001-9913-9034","position":3,"is_corresponding":false},{"id":786111,"name":"Raphael Ondondo","orcid":"0000-0001-5922-7208","position":4,"is_corresponding":false},{"id":1414494,"name":"Irma Castro","orcid":"0000-0002-5605-3422","position":5,"is_corresponding":false},{"id":973253,"name":"Aric Schadler","orcid":"0000-0001-8814-5834","position":6,"is_corresponding":false},{"id":264706,"name":"Kristen McQuerry","orcid":"0000-0002-0130-4335","position":7,"is_corresponding":false},{"id":942364,"name":"George J. Fuchs","orcid":"0000-0002-8679-8265","position":8,"is_corresponding":false},{"id":258316,"name":"Janet E. Williams","orcid":"0000-0002-9769-1789","position":9,"is_corresponding":false},{"id":1414939,"name":"Katlyn N Scarrow","orcid":null,"position":10,"is_corresponding":false},{"id":258321,"name":"Mark A. McGuire","orcid":"0000-0003-4329-0450","position":11,"is_corresponding":false},{"id":752739,"name":"Michelle K McGuire","orcid":null,"position":12,"is_corresponding":false},{"id":429696,"name":"Carrie Waterman","orcid":"0000-0003-3986-7034","position":13,"is_corresponding":false},{"id":860547,"name":"Suzanna Attia","orcid":"0000-0002-2689-3340","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T02:51:27.893975Z","pmid":"41282517","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}